Protein Information

Name alkaline phosphatase
Synonyms ALP 1; Alkaline phosphatase; ALPG; ALPPL; ALPPL 2; ALPPL2; GCAP; Germ cell alkaline phosphatase…

Compound Information

Name ergocalciferol
CAS

Reference List

PubMed Abstract RScore(About this table)
10327872 Glerup H, Eriksen EF: [Vitamin D deficiency. Ugeskr Laeger. 1999 Apr 26;161(17):2515-21.

If the patient also has raised values of PTH or alkaline phosphatase an intramuscular dose of 100,000 IU ergocalciferol pr week for one month is given.
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302527 Petrova EA, Miloserdova AG, Babaskina LI: [Toxic action of ergocalciferol in strontium rickets] . Vopr Pitan. 1977 Mar-Apr;(2):41-3.

Tests conducted on albino rats of the Wistar line demonstrated that introduction of large doses of ergocalciferol (vitamin D2) to animals kept on a strontium-rich diet exhibiting signs of rickets brings about the development in them of specific manifestations of the D-vitamin activity, viz. rising level of calcium, strontium and inorganic phosphorus in the blood serum, lowering of the alkaline phosphatase activity and a greater degree of the soft tissues calcification.
6(0,0,1,1) Details
16856326 Shiau SY, Hwang JY: The dietary requirement of juvenile grass shrimp (Penaeus monodon) for vitamin D. J Nutr. 1994 Dec;124(12):2445-50.

In Experiment 1, purified diets with six levels (0, 0.1, 0.5, 2.5, 12.5 and 62.5 mg/kg diet) of supplemental ergocalciferol and cholecalciferol were fed to P. monodon (mean weight 0.19 +/- 0.02 g).
The feed efficiency ratio and alkaline phosphatase activity generally followed the same pattern as the weight gain.
2(0,0,0,2) Details
18463042 Alzahrani AS, Al Sheef M: Severe primary hyperparathyroidism masked by asymptomatic celiac disease. . Endocr Pract. 2008 Apr;14(3):347-50.

Laboratory data (and reference ranges) were as follows: serum calcium, 2.34 mmol/L (2.1 to 2.6); phosphorus, 0.91 mmol/L (0.90 to 1.50); alkaline phosphatase, 421 U/L (40 to 135); albumin, 37 g/L (35 to 45); parathyroid hormone, 874 ng/L (15 to 65); urine calcium, 3.76 mmol/d (2.5 to 8); and 25-hydroxyvitamin D, <13 nmol/L (22 to 116).
She was treated with increasing doses of calcitriol, ergocalciferol, and calcium carbonate, but the serum calcium concentration did not increase substantially (reaching a maximum of 2.70 mmol/L on suprapharmacologic doses of these agents).
1(0,0,0,1) Details
18308659 Camacho PM, Painter S, Kadanoff R: Treatment of adult hypophosphatasia with teriparatide. Endocr Pract. 2008 Mar;14(2):204-8.

METHODS: A 75-year-old woman with hypophosphatasia was treated with ergocalciferol and calcium supplements for 2 years.
Baseline biochemical values (and reference ranges) were as follows: serum total alkaline phosphatase ranged from 14 to 17 U/L (30 to 110), bone-specific alkaline phosphatase (BSALP) was 5 U/L (14 to 43), serum phosphorus was elevated at 5.4 mg/dL (2.6 to 4.4), and pyridoxal 5'-phosphate was high at 250 ng/mL (5 to 30).
2(0,0,0,2) Details
11107965 Glerup H: [Vitamin D deficiency among immigrants] . Ugeskr Laeger. 2000 Nov 13;162(46):6196-9.

The diagnosis can be tested by three blood tests: serum 25-hydroxyvitamin D, serum PTH, and serum alkaline phosphatase.
If a combination of low 25-hydroxyvitamin D and secondary hyperparathyroidism is found, the treatment should be high-dose ergocalciferol or cholecalciferol (100,000 IU weekly).
1(0,0,0,1) Details
11715587 Grootjans-Geerts I: [Hypovitaminosis D: a veiled diagnosis] . Ned Tijdschr Geneeskd. 2001 Oct 27;145(43):2057-60.

Calcium and serum alkaline phosphatase activity may be normal.
Treatment with ergocalciferol is effective and cheap.
1(0,0,0,1) Details
19661219 Kalantar-Zadeh K, Kovesdy CP: Clinical outcomes with active versus nutritional vitamin D compounds in chronic kidney disease. Clin J Am Soc Nephrol. 2009 Sep;4(9):1529-39. Epub 2009 Aug 6.

Some opinion-based guidelines recommend administration of such nutritional vitamin D agents as ergocalciferol or cholecalciferol as the first therapy in hyperparathyroidism associated with low circulating levels of 25-hydroxy vitamin D (<30 ng/ml) in nondialysis dependent CKD patients.
Compared with nutritional vitamin D agents, active vitamin D compounds appear to more effectively lower the circulating levels of alkaline phosphatase, a conveniently available biomarker associated with increased mortality and coronary artery calcification in CKD patients.
1(0,0,0,1) Details
8865145 Heikinheimo R, Sievanen H, Jantti P, Maki-Jokela PL, Rajala S, Vuori I: Vitamin D treatment and bone mineral density in the aged. Maturitas. 1996 May;23 Suppl:S77-80.

The bone mineral density in the distal forearm and femoral neck did not differ between nine residents (mean age 81.0 years) of an old peoples' home who had received an annual injection of 150,000 IU ergocalciferol during the foregoing 2-7 years (mean 5.1 years) and nine age-, weight- and height-matched control subjects who had subnormal 25 hydroxyvitamin D level.
The alkaline phosphatase and parathyroid hormone levels were clearly higher when the 25 hydroxyvitamin D level was below 10 nmol/1.
1(0,0,0,1) Details
17389892 Hernandez JD, Wesseling K, Boechat MI, Gales B, Salusky IB: Osteomalacia in a hemodialysis patient receiving an active vitamin D sterol. Nat Clin Pract Nephrol. 2007 Apr;3(4):227-32.

INVESTIGATIONS: The patient underwent a physical examination, and his serum levels of calcium, phosphorus, alkaline phosphatase, parathyroid hormone, aluminum and 25-hydroxycholecalciferol (25OH-vitamin D) were determined.
MANAGEMENT: Monthly therapy with ergocalciferol (vitamin D2) and discontinuation of paricalcitol.
1(0,0,0,1) Details
12186406 Hata K, Sugawara F, Ohisa N, Takahashi S, Hori K: Stimulative effects of (22E,24R)-ergosta-7,22-diene-3beta,5alpha,6beta-triol from fruiting bodies of Tricholoma auratum, on a mouse osteoblastic cell line, MC3T3-E1. Biol Pharm Bull. 2002 Aug;25(8):1040-4.

Sixteen phosphate buffered saline (PBS), 8 boiled PBS, 14 ethanol and 12 methanol extracts induced alkaline phosphatase (ALP) activities, an indicator of MC3T3-E1 cell differentiation.
To investigate the relationships between the chemical structure and differentiation-inducing activity of the compound, ALP-inducing activities of MC3T3-E1 cells by 1, ergosterol (2), ergocalciferol (3), cholesta-3beta3,5alpha6beta-triol (4), 7-dehydrocholesterol (5) and cholecalciferol (6) were tested.
1(0,0,0,1) Details
3877585 Hodson EM, Evans RA, Dunstan CR, Hills E, Wong SY, Rosenberg AR, Roy LP: Treatment of childhood renal osteodystrophy with calcitriol or ergocalciferol. Clin Nephrol. 1985 Oct;24(4):192-200.

Plasma calcium levels rose while parathyroid hormone and alkaline phosphatase levels fell following both treatments, and were unchanged in non-compliant children.
1(0,0,0,1) Details
9062528 Zeghoud F, Vervel C, Guillozo H, Walrant-Debray O, Boutignon H, Garabedian M: Subclinical vitamin D deficiency in neonates: definition and response to vitamin D supplements. Am J Clin Nutr. 1997 Mar;65(3):771-8.

To determine the biological criteria for neonatal vitamin D deficiency, serum 25-hydroxyvitamin D (calcidiol), parathyroid hormone (PTH), calcium, phosphates, and alkaline phosphatase (ALP) activity were measured during the winter-spring period in 80 healthy neonates and their mothers 3-6 d after delivery.
A longitudinal 3-mo survey of the serum biology of 52 of these neonates consuming formula was also performed to test the influence of their neonatal vitamin D status on the effects of two oral ergocalciferol supplements (500 and 1000 IU or 12.5 and 25 micrograms/d).
1(0,0,0,1) Details
6989438 Brooke OG, Brown IR, Bone CD, Carter ND, Cleeve HJ, Maxwell JD, Robinson VP, Winder SM: Vitamin D supplements in pregnant Asian women: effects on calcium status and fetal growth. Br Med J. 1980 Mar 15;280(6216):751-4.

In a double-blind trial of vitamin D supplements in pregnant Asian women calciferol (ergocalciferol, 1000 IU/day) was administered to 59 women and placebo to 67 controls during the last trimester.
Mothers in the treatment group gained weight faster in the last trimester than those in the control group, and at term they and their infants all had adequate plasma 25-OHD concentrations, Mothers and infants in the control group, however, had low plasma concentrations of 25-OHD and calcium and raised plasma alkaline phosphatase (bone isoenzyme) activity.
1(0,0,0,1) Details
18937749 Rajah J, Jubeh JA, Haq A, Shalash A, Parsons H: Nutritional rickets and z scores for height in the United Arab Emirates: to D or not to D?. Pediatr Int. 2008 Aug;50(4):424-8.

The alkaline phosphatase (ALP) was negatively correlated to z scores, implying that higher ALP concentrations predicted severe bone disease (lower z scores).
A cohort of patients with nutritional rickets was treated with vitamin D (2) (ergocalciferol) alone.
1(0,0,0,1) Details
11335767 Carvalho NF, Kenney RD, Carrington PH, Hall DE: Severe nutritional deficiencies in toddlers resulting from health food milk alternatives. Pediatrics. 2001 Apr;107(4):E46.

The serum alkaline phosphatase was markedly elevated (1879 U/L), phosphorus was low (1.7 mg/dL), and calcium was low normal (8.9 mg/dL).
The patient was treated with ergocalciferol and calcium supplements.
1(0,0,0,1) Details
195455 Arnaud SB, Matthusen M, Gilkinson JB, Goldsmith RS: Components of 25-hydroxyvitamin D in serum of young children in upper midwestern United States. Am J Clin Nutr. 1977 Jul;30(7):1082-6.


The relative importance of cholecalciferof (vitamin D3) and ergocalciferol (vitamin D2) in maintaining the vitamin D level in children (1/2 to 6 years old) living in the upper midwestern United States was determined by measurement of total 25-hydroxyvitamin D (25-OH-D), its components, and other indices of calcium homeostasis in serum.
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