| Name | hCE 2 |
|---|---|
| Synonyms | CE 2; ICE; CES 2; CES2; CES2 protein; Carboxylesterase 2; Carboxylesterase 2 isoform 1 variant; Carboxylesterase 2 precursor… |
| Name | permethrin |
|---|---|
| CAS | (3-phenoxyphenyl)methyl 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16387282 | Ross MK, Borazjani A, Edwards CC, Potter PM: Hydrolytic metabolism of pyrethroids by human and other mammalian carboxylesterases. Biochem Pharmacol. 2006 Feb 28;71(5):657-69. Epub 2006 Jan 4. We also determined that the CE inhibitor 2-chloro-3,4-dimethoxybenzil blocked hCE-2-catalyzed trans-permethrin hydrolysis 36 times more potently than hCE-1. |
113(1,2,2,3) | Details |
| 16359636 | Nishi K, Huang H, Kamita SG, Kim IH, Morisseau C, Hammock BD: Characterization of pyrethroid hydrolysis by the human liver carboxylesterases hCE-1 and hCE-2. Arch Biochem Biophys. 2006 Jan 1;445(1):115-23. For example, the trans-isomers of permethrin and cypermethrin were hydrolyzed much faster than corresponding cis-counterparts by both enzymes. |
4(0,0,0,4) | Details |
| 17442360 | Crow JA, Borazjani A, Potter PM, Ross MK: Hydrolysis of pyrethroids by human and rat tissues: examination of intestinal, liver and serum carboxylesterases. Toxicol Appl Pharmacol. 2007 May 15;221(1):1-12. Epub 2007 Mar 12. The major esterase in human intestine is carboxylesterase 2 (hCE2). We found that the pyrethroid trans-permethrin is effectively hydrolyzed by a sample of pooled human intestinal microsomes (5 individuals), while deltamethrin and bioresmethrin are not. |
1(0,0,0,1) | Details |