Protein Information

Name cytochrome c
Synonyms CYC; CYCS; Cytochrome C; HCS; Cytochrome Cs

Compound Information

Name permethrin
CAS (3-phenoxyphenyl)methyl 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate

Reference List

PubMed Abstract RScore(About this table)
12587253 Abu-Qare AW, Abou-Donia MB: Combined exposure to DEET (N,N-diethyl-m-toluamide) and permethrin: pharmacokinetics and toxicological effects. J Toxicol Environ Health B Crit Rev. 2003 Jan-Feb;6(1):41-53.

Concurrent application of DEET and permethrin induced urinary excretion of 3-nitrotyrosine and 8-hydroxy-2'-deoxyguanosine, markers of DNA damage and oxidative stress in rats, increased the release of rat brain mitochondrial cytochrome c, disrupted the blood-brain barrier (BBB) in rats, decreased m2 muscarinic acetylcholine receptor ligand binding density in rat brain, increased urinary excretion of 6 beta-hydroxycortisol, a marker CYP3A4 induction, altered sensorimotor and locomotor activities in rats, and changed in vivo and in vitro metabolism and pharmacokinetic profiles of the individual compound.
31(0,1,1,1) Details
11437058 Abu-Qare AW, Abou-Donia MB: Combined exposure to DEET (N,N-diethyl-m-toluamide) and permethrin-induced release of rat brain mitochondrial cytochrome c. J Toxicol Environ Health A. 2001 Jun 22;63(4):243-52.
27(0,0,4,7) Details
18533432 Zhao L, Pridgeon JW, Becnel JJ, Clark GG, Linthicum KJ: Cytochrome c gene and protein expression: developmental regulation, environmental response, and pesticide sensitivity in Aedes aegypti. J Med Entomol. 2008 May;45(3):401-8.

We also investigated the effect of certain environmental factors (e.g., temperature, UV-light, and permethrin insecticide) on AeaCytC gene and AeaCYTC protein expression in adult mosquitoes, and we found that response varied with age.
5(0,0,0,5) Details
3083808 Scott JG, Georghiou GP: The biochemical genetics of permethrin resistance in the Learn-PyR strain of house fly. Biochem Genet. 1986 Feb;24(1-2):25-37.

Three factors were associated with resistance: (1) increased mixed-function oxidase (MFO) activity associated with elevated levels of cytochrome P-450, cytochrome b5, and NADPH-cytochrome c reductase (P-450 reductase) activity; (2) target-site insensitivity (kdr); and (3) decreased cuticular penetration.
1(0,0,0,1) Details
6768169 Carlson GP, Schoenig GP: Induction of liver microsomal NADPH cytochrome C reductase and cytochrome P-450 by some new synthetic pyrethroids. Toxicol Appl Pharmacol. 1980 Mar 15;52(3):507-12.

1(0,0,0,1) Details