| Name | estrogen receptor alpha |
|---|---|
| Synonyms | ER; ERA; ER alpha; ERalpha; ESR; ESR 1; ESR1; ESRA… |
| Name | permethrin |
|---|---|
| CAS | (3-phenoxyphenyl)methyl 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16395479 | McCarthy AR, Thomson BM, Shaw IC, Abell AD: Estrogenicity of pyrethroid insecticide metabolites. . J Environ Monit. 2006 Jan;8(1):197-202. Epub 2005 Dec 14. It has been noted that some metabolites of pyrethroids, in particular, permethrin and cypermethrin, have chemical structures that are more likely to interact with the cellular estrogen receptor than the parent pyrethroid. |
83(1,1,1,3) | Details |
| 10966511 | Saito K, Tomigahara Y, Ohe N, Isobe N, Nakatsuka I, Kaneko H: Lack of significant estrogenic or antiestrogenic activity of pyrethroid insecticides in three in vitro assays based on classic estrogen receptor alpha-mediated mechanisms. Toxicol Sci. 2000 Sep;57(1):54-60. Estrogenic and antiestrogenic activity of pyrethroid insecticides (d-trans-allethrin, cypermethrin, empenthrin, fenvalerate, imiprothrin, permethrin, d-phenothrin and prallethrin) was evaluated using a suite of three in vitro assays based on classic human estrogen receptor alpha (hER alpha)-mediated mechanisms. |
32(0,1,1,2) | Details |
| 12396874 | Chen H, Xiao J, Hu G, Zhou J, Xiao H, Wang X: Estrogenicity of organophosphorus and pyrethroid pesticides. J Toxicol Environ Health A. 2002 Oct 11;65(19):1419-35. The present study was undertaken to evaluate the estrogenic activities of nine pesticides (phoxim, malathion, monocrotophos, dimethoate, opunal, fenvalerate, cypermethrin, permethrin, and deltamethrin) using three in vitro methods [E-Screen assay, estrogen receptor (ER) competitive binding assay, and pS2 expression assay]. |
31(0,1,1,1) | Details |
| 12052007 | Kunimatsu T, Yamada T, Ose K, Sunami O, Kamita Y, Okuno Y, Seki T, Nakatsuka I: Lack of (anti-) androgenic or estrogenic effects of three pyrethroids (esfenvalerate, fenvalerate, and permethrin) in the Hershberger and uterotrophic assays. Regul Toxicol Pharmacol. 2002 Apr;35(2 Pt 1):227-37. In the present study, we evaluated the interaction of three pyrethroids (esfenvalerate, fenvalerate, and permethrin) with androgen receptor (AR)- and estrogen receptor (ER)-mediated mechanisms using in vivo short-term assays. |
31(0,1,1,1) | Details |
| 15118252 | Kim IY, Shin JH, Kim HS, Lee SJ, Kang IH, Kim TS, Moon HJ, Choi KS, Moon A, Han SY: Assessing estrogenic activity of pyrethroid insecticides using in vitro combination assays. J Reprod Dev. 2004 Apr;50(2):245-55. In addition, we measured estrogen receptor (ER) protein and pS2 mRNA levels in human breast cancer cells (MCF-7 BUS) to clarify the mechanism of their estrogenicity. Seven pyrethroid insecticides (bioallethrine, cypermethrin, deltamethrin, fenvalerate, permethrin, sumithrin, and tetramethrin) were tested because of their worldwide usage. |
2(0,0,0,2) | Details |
| 16896612 | Dhooge W, Arijs K, D'Haese I, Stuyvaert S, Versonnen B, Janssen C, Verstraete W, Comhaire F: Experimental parameters affecting sensitivity and specificity of a yeast assay for estrogenic compounds: results of an interlaboratory validation exercise. Anal Bioanal Chem. 2006 Nov;386(5):1419-28. Epub 2006 Aug 3. Therefore it fulfills the requirements as a first step screening assay to evaluate the capacity of chemicals to interact with the estrogen receptor. |
1(0,0,0,1) | Details |