Protein Information

Name FMO2
Synonyms Dimethylaniline monooxygenase 4; FMO2; Dimethylaniline monooxygenase [N oxide forming] 4; Dimethylaniline oxidase 4; FMO 4; FMO4; Flavin containing monooxygenase 4; Hepatic flavin containing monooxygenase 4…

Compound Information

Name phorate
CAS

Reference List

PubMed Abstract RScore(About this table)
11835629 Karoly ED, Rose RL: Sequencing, expression, and characterization of cDNA expressed flavin-containing monooxygenase 2 from mouse. J Biochem Mol Toxicol. 2001;15(6):300-8.

The expressed FMO2 enzyme showed catalytic activity towards the FMO substrate methimazole and further analysis of E. coli fractions utilizing NADPH oxidation demonstrated that the mouse FMO2 enzyme also exhibits catalytic activity towards thiourea, trimethylamine, and the insecticide phorate.
36(0,1,1,6) Details
15294458 Henderson MC, Krueger SK, Siddens LK, Stevens JF, Williams DE: S-oxygenation of the thioether organophosphate insecticides phorate and disulfoton by human lung flavin-containing monooxygenase 2. Biochem Pharmacol. 2004 Sep 1;68(5):959-67.

The major FMO in lung of most mammals, including non-human primates, is FMO2.
1(0,0,0,1) Details