| Name | thioredoxin reductase |
|---|---|
| Synonyms | ACR 1; PLP; ACR1; AOEB166; Alu corepressor 1; Antioxidant enzyme B166; B166; Liver tissue 2D page spot 71B… |
| Name | phosphine |
|---|---|
| CAS | phosphine |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19937669 | Vergara E, Casini A, Sorrentino F, Zava O, Cerrada E, Rigobello MP, Bindoli A, Laguna M, Dyson PJ: Anticancer therapeutics that target selenoenzymes: synthesis, characterization, in vitro cytotoxicity, and thioredoxin reductase inhibition of a series of gold (I) complexes containing hydrophilic phosphine ligands. ChemMedChem. 2010 Jan;5(1):96-102. |
82(1,1,1,2) | Details |
| 19665452 | Gandin V, Fernandes AP, Rigobello MP, Dani B, Sorrentino F, Tisato F, Bjornstedt M, Bindoli A, Sturaro A, Rella R, Marzano C: Cancer cell death induced by phosphine gold (I) compounds targeting thioredoxin reductase. Biochem Pharmacol. 2010 Jan 15;79(2):90-101. Epub 2009 Aug 7. |
8(0,0,1,3) | Details |
| 15025511 | Waters SB, Devesa V, Del Razo LM, Styblo M, Thomas DJ: Endogenous reductants support the catalytic function of recombinant rat cyt19, an arsenic methyltransferase. Chem Res Toxicol. 2004 Mar;17(3):404-9. The reductants or tris (2-carboxylethyl) phosphine support catalysis by recombinant rat cyt19 (rrcyt19). Coupled systems containing an endogenous reductant (thioredoxin/thioredoxin reductase/ glutaredoxin//glutathione reductase/ or /thioredoxin reductase/ support inorganic As methylation by rrcyt19. |
2(0,0,0,2) | Details |
| 14975452 | Landino LM, Iwig JS, Kennett KL, Moynihan KL: Repair of damage to tubulin by the thioredoxin reductase system. Free Radic Biol Med. 2004 Feb 15;36(4):497-506. The extent of activity restored by thioredoxin reductase and by the nonspecific disulfide-reducing agent tris (2-carboxyethyl) phosphine hydrochloride was identical; however, activity was not restored to control levels. |
6(0,0,0,6) | Details |
| 16510263 | Omata Y, Folan M, Shaw M, Messer RL, Lockwood PE, Hobbs D, Bouillaguet S, Sano H, Lewis JB, Wataha JC: Sublethal concentrations of diverse gold compounds inhibit mammalian cytosolic thioredoxin reductase (TrxR1). Toxicol In Vitro. 2006 Sep;20(6):882-90. Epub 2006 Feb 28. METHODS: We exposed rat-TrxR1 to auranofin, gold thiomalate, aurothiosulfate, triphenyl phosphine gold or gold and measured TrxR activity ex vivo. |
2(0,0,0,2) | Details |
| 17697672 | Rackham O, Nichols SJ, Leedman PJ, Berners-Price SJ, Filipovska A: A gold (I) phosphine complex selectively induces apoptosis in breast cancer cells: implications for anticancer therapeutics targeted to mitochondria. Biochem Pharmacol. 2007 Oct 1;74(7):992-1002. Epub 2007 Jul 21. To address the molecular basis of the observed selectivity between the two cell lines we investigated the effect of the gold complex on the thioredoxin/thioredoxin reductase system in normal and cancer breast cells. |
2(0,0,0,2) | Details |
| 18242600 | Rigobello MP, Folda A, Dani B, Menabo R, Scutari G, Bindoli A: Gold (I) complexes determine apoptosis with limited oxidative stress in Jurkat T cells. Eur J Pharmacol. 2008 Mar 17;582(1-3):26-34. Epub 2008 Jan 4. Interestingly, the gold (I) compound aurothiomalate was poorly effective, both in inhibiting thioredoxin reductase and in inducing apoptosis. |
1(0,0,0,1) | Details |
| 19123857 | Ott I, Qian X, Xu Y, Vlecken DH, Marques IJ, Kubutat D, Will J, Sheldrick WS, Jesse P, Prokop A, Bagowski CP: A gold (I) phosphine complex containing a naphthalimide ligand functions as a TrxR inhibiting antiproliferative agent and angiogenesis inhibitor. J Med Chem. 2009 Feb 12;52(3):763-70. Mechanistic experiments indicated that the inhibition of thioredoxin reductase (based on the covalent binding of a gold triethylphosphine fragment) might be involved in the pharmacodynamic behavior of this novel gold species. |
1(0,0,0,1) | Details |