| 18475846 |
McKeage MJ, Papathanasiou P, Salem G, Sjaarda A, Swiegers GF, Waring P, Wild SB: Antitumor activity of gold (i), silver (i) and copper (i) complexes containing chiral tertiary phosphines. Met Based Drugs. 1998;5(4):217-23.
The in vitro cytotoxicities of gold (I) and silver (I) complexes containing the optically active forms of the tetra (tertiary phosphine) have also been examined against the human ovarian carcinoma cell lines 41M and CH1, and the cisplatin resistant 41McisR, CH1cisR and SKOV-3 tumour models. |
31(0,1,1,1) |
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| 18029019 |
Liu JJ, Galettis P, Farr A, Maharaj L, Samarasinha H, McGechan AC, Baguley BC, Bowen RJ, Berners-Price SJ, McKeage MJ: In vitro antitumour and hepatotoxicity profiles of Au (I) and Ag (I) bidentate pyridyl phosphine complexes and relationships to cellular uptake. J Inorg Biochem. 2008 Feb;102(2):303-10. Epub 2007 Sep 26.
The gold and silver compounds overcame cisplatin-resistance in the CH1-cisR, 41M-cisR and SKOV-3 cell-lines, and showed cytotoxic potencies strongly correlated with their lipophilicity. |
1(0,0,0,1) |
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