| 15646645 |
Nawrot B, Michalak O, De Clercq E, Stec WJ: Analogues of acyclic nucleosides derived from tris-(hydroxymethyl) phosphine oxide or bis-(hydroxymethyl) phosphinic acid coupled to DNA nucleobases. Antivir Chem Chemother. 2004 Nov;15(6):319-28.
A series of novel acyclic nucleoside analogues containing bis-(hydroxymethyl) phosphinic acid (BHPA) or tris (hydroxymethyl) phosphine oxide (THPO) coupled with DNA nucleobases or with 5-fluorouracil were prepared and their antiviral activity was studied against cytomegalovirus (CMV), varicella-zoster virus (VZV), parainfluenza-virus type 3, reovirus-type 1, sindbis, coxsackie B4, punta toro, vesicular stomatitis and respiratory syncytial virus, herpes simplex virus-type 1 (KOS) and type 2 (G), vaccinia virus and herpes simplex virus-1 (TK- KOS ACVr). |
31(0,1,1,1) |
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