| 15898735 |
Fernandes C, Correia JD, Gano L, Santos I, Seifert S, Syhre R, Bergmann R, Spies H: Dramatic effect of the tridentate ligand on the stability of 99mTC "3 + 1" oxo complexes bearing arylpiperazine derivatives. Bioconjug Chem. 2005 May-Jun;16(3):660-8.
The activity in the brain (% dose injected/organ) at 5 min (0.14% +/- 0.03) and 120 min (0.11% +/- 0.02) pi encouraged the synthesis of several mixed-ligand "3 + 1" oxo complexes of general formula [M (O)(kappa (3)-PNS)(kappa (1)-SL))] (M = (99m) Tc, 3a-6a, Re, 3-6), in which the tridentate ligand is the heterofunctionalized phosphine 2-(diphenylphosphanyl)-N-(2-thioethyl) benzamide (PNS) and the co-ligands are different arylpiperazine derivatives (HSL1-HSL4). |
81(1,1,1,1) |
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