Protein Information

Name Protein S
Synonyms PROS; PSA; PROS 1; PROS 2; PROS1; PROS2; PROSP; PS 26…

Compound Information

Name phosphine
CAS phosphine

Reference List

PubMed Abstract RScore(About this table)
16540105 Hsu MF, Chen YS, Huang LJ, Tsao LT, Kuo SC, Wang JP: GEA3162, a nitric oxide-releasing agent, activates non-store-operated Ca2+ entry and inhibits store-operated Ca2+ entry pathways in neutrophils through thiol oxidation. Eur J Pharmacol. 2006 Mar 27;535(1-3):43-52. Epub 2006 Mar 15.

The dual effects of GEA3162 on the regulation of the external Ca2+ entry are mainly through the thiol modification of target protein (s) residing on the outside of the plasma membrane.
This Ca2+ response was prevented by the thiol reducing agents, 2-mercaptoethanol, N-acetyl-L-cysteine, dithiothreitol, 2,3-dimercaptopropane-1-sulfonic acid (DMPS) and tris-(2-carboxyethyl) phosphine (TCEP), but slightly reduced by the antioxidant, 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (Trolox).
1(0,0,0,1) Details
19325988 David C, Foley S, Enescu M: Protein S-S bridge reduction: a Raman and computational study of lysozyme interaction with TCEP. Phys Chem Chem Phys. 2009 Apr 14;11(14):2532-42. Epub 2009 Feb 13.

The experimental kinetics of S-S bridge reduction by tris-2-carboxyethyl phosphine (TCEP) was obtained by monitoring the protein S-S Raman bands.
32(0,1,1,2) Details
19715315 Wang H, Zhang J, Xian M: Facile formation of dehydroalanine from S-nitrosocysteines. J Am Chem Soc. 2009 Sep 23;131(37):13238-9.

A reductive elimination of S-nitrosocysteines using phosphine substrates has been developed.
It can potentially be applied for the detection of protein S-nitrosation.
1(0,0,0,1) Details
20146502 Bechtold E, Reisz JA, Klomsiri C, Tsang AW, Wright MW, Poole LB, Furdui CM, King SB: Water-Soluble Triarylphosphines as Biomarkers for Protein S-Nitrosation. ACS Chem Biol. 2010 Feb 18.

Herein, we report the reaction of S-nitrosated cysteine, glutathione, and a mutated C165S alkyl hydroperoxide reductase with the water-soluble phosphine tris (4,6-dimethyl-3-sulfonatophenyl) phosphine trisodium salt hydrate (TXPTS).
1(0,0,0,1) Details