| Name | Acetylcholinesterase |
|---|---|
| Synonyms | ACHE; ACHE protein; AChE; ARACHE; AcChoEase; Acetylcholine acetylhydrolase; Acetylcholinesterase; Acetylcholinesterase isoform E4 E6 variant… |
| Name | phoxim |
|---|---|
| CAS | 4-ethoxy-7-phenyl-3,5-dioxa-6-aza-4-phosphaoct-6-ene-8-nitrile 4-sulfide |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 12411190 | Li J, Zhang Y, Du X, Sun M: [Reactivation and aging of acetylcholinesterase in human brain inhibited by phoxim and phoxim oxon in vitro]. Zhonghua Yu Fang Yi Xue Za Zhi. 2002 Sep;36(5):311-4. |
487(6,6,6,7) | Details |
| 17534602 | Zhang YH, Miyata T, Wu ZJ, Wu G, Xie LH: Hydrolysis of acetylthiocholine iodide and reactivation of phoxim-inhibited acetylcholinesterase by pralidoxime chloride, obidoxime and trimedoxime. Arch Toxicol. 2007 Nov;81(11):785-92. Epub 2007 May 30. |
244(3,3,3,4) | Details |
| 7816740 | Koutsoviti-Papadopoulou M, Kounenis G, Elezoglou V: Ketamine protects acetylcholinesterase against inhibition by propoxur and phoxim. Pharmacol Res. 1994 Aug-Sep;30(2):117-22. |
168(2,2,3,3) | Details |
| 18615705 | Yang ML, Zhang JZ, Zhu KY, Xuan T, Liu XJ, Guo YP, Ma EB: Mechanisms of organophosphate resistance in a field population of oriental migratory locust, Locusta migratoria manilensis (Meyen). Arch Insect Biochem Physiol. 2009 May;71(1):3-15. The susceptibilities to three organophosphate (OP) insecticides (malathion, chlorpyrifos, and phoxim), responses to three metabolic synergists [triphenyl (TPP), piperonyl butoxide (PBO), and diethyl (DEM)], activities of major detoxification enzymes [general esterases (ESTs), glutathione S-transferases (GSTs), and cytochrome P450 monooxygenases (P450s)], and sensitivity of the target enzyme acetylcholinesterase (AChE) were compared between a laboratory-susceptible strain (LS) and a field-resistant population (FR) of the oriental migratory locust, Locusta migratoria manilensis (Meyen). |
63(0,2,2,3) | Details |
| 12107655 | Moretto A, Lotti M: The relationship between isofenphos cholinergic toxicity and the development of polyneuropathy in hens and humans. Arch Toxicol. 2002 Jun;76(5-6):367-75. Epub 2002 May 16. To explain this difference the following hypotheses were tested: (1) phoxim is a promoter of isofenphos-induced OPIDP; (2) whereas neuropathy target esterase (NTE) is thought to be the target of OPIDP, activation of isofenphos by liver microsomes causes the formation of more potent NTE inhibitor (s) in humans than in hens; (3) in contrast to hen NTE, the sensitivity of the human enzyme to such inhibitor (s) is higher than that of acetylcholinesterase (AChE), the target of cholinergic toxicity. |
33(0,1,1,3) | Details |
| 17974266 | Zhang YL, Mu W, Chen ZL, Han ZR, Ma C, Zhai RH: [Susceptibility and related physiological and biochemical mechanisms of Carposina niponensis Walsingham larvae on six insecticides before and after overwintering]. Ying Yong Sheng Tai Xue Bao. 2007 Aug;18(8):1913-6. The study with impregnating method showed that after overwintering, the susceptibility of Carposina niponensis larvae on triazophos, phoxim, chlorpyrifos, malathion, lambda-cyhalothrin and abamectin was 34.50, 16.71, 3.89, 3.28, 5.90 and 2.73 times as much as that before overwintering, the total protein, and fat contents and carboxylesterase, acid phosphatase, alkaline phosphatase, glutathione-S-transferase, superoxide dismutase, catalase and peroxidase activities in C. niponensis larvae were decreased by 17.10%, 41.76% and 30.08%, 62.36%, 53.47%, 76.19%, 80.60%, 18.77%, 14.16% and 64.02%, respectively, and the activity of acetylcholinesterase, the target enzyme of many insecticides, was 1.41 times as much as that before overwintering. |
31(0,1,1,1) | Details |
| 3245355 | Shataeva GA, Makhaeva GF, Iankovskaia VL, Sokolov VB, Ivanov AN: [Comparative study of the interaction of acetylcholinesterases of human erythrocytes and the heads of houseflies with phosphorylated alkylchloroformoximes]. Zh Evol Biokhim Fiziol. 1988 Nov-Dec;24(6):791-6. |
4(0,0,0,4) | Details |
| 15793557 | Isoda H, Talorete TP, Han J, Oka S, Abe Y, Inamori Y: Effects of organophosphorous pesticides used in china on various mammalian cells. Environ Sci. 2005;12(1):9-19. Five organophosphorous pesticides, monocrotophos, omethoate, parathion-methyl, phoxim and dichlorvos, were examined for their effects on mammalian cell lines to determine their potential impact on physiological functions in vivo. The different pesticides reduced the acetylcholinesterase (AChE) activity of the rat neuronal cell line PC12 in a dose-dependent manner up to 100 microM. |
1(0,0,0,1) | Details |
| 17386802 | Ni Y, Cao D, Kokot S: Simultaneous enzymatic kinetic determination of pesticides, carbaryl and phoxim, with the aid of chemometrics. Anal Chim Acta. 2007 Apr 4;588(1):131-9. Epub 2007 Feb 6. It was based on the inhibitory effect of the pesticides on acetylcholinesterase (AChE), and the use of 5,5'-dithiobis (2-nitrobenzoic) acid (DTNB) as a chromogenic reagent for the thiocholine iodide (TChI) released from the acetylthiocholine iodide (ATChI) substrate. |
1(0,0,0,1) | Details |