| Name | CYP17 |
|---|---|
| Synonyms | CPT 7; CPT7; CYP17; CYP17A1; CYPXVII; Cytochrome P450 17A1; Cytochrome p450 XVIIA1; P450 C17… |
| Name | prochloraz |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19733639 | Ohlsson A, Ulleras E, Oskarsson A: A biphasic effect of the fungicide prochloraz on but not secretion in human H295R cells--underlying mechanisms. Toxicol Lett. 2009 Dec 15;191(2-3):174-80. Epub 2009 Sep 4. Analysis of the dose-dependent effects of prochloraz on the secretion of steroidogenic intermediates suggested that the observed effects on and secretion might be mediated by inhibition of the steroidogenic steps catalysed by CYP17A1 and CYP21A2. |
82(1,1,1,2) | Details |
| 19767443 | Ankley GT, Bencic DC, Cavallin JE, Jensen KM, Kahl MD, Makynen EA, Martinovic D, Mueller ND, Wehmas LC, Villeneuve DL: Dynamic nature of alterations in the endocrine system of fathead minnows exposed to the fungicide prochloraz. Toxicol Sci. 2009 Dec;112(2):344-53. Epub 2009 Sep 18. In male fathead minnows, the 8-day prochloraz exposure decreased (T) production, possibly through inhibition of CYP17. |
81(1,1,1,1) | Details |
| 17369198 | Blystone CR, Lambright CS, Howdeshell KL, Furr J, Sternberg RM, Butterworth BC, Durhan EJ, Makynen EA, Ankley GT, Wilson VS, Leblanc GA, Gray LE Jr: Sensitivity of fetal rat testicular steroidogenesis to maternal prochloraz exposure and the underlying mechanism of inhibition. Toxicol Sci. 2007 Jun;97(2):512-9. Epub 2007 Mar 15. These results suggest that PCZ inhibits the conversion of to through the inhibition of CYP17. |
5(0,0,0,5) | Details |
| 16375936 | Laier P, Metzdorff SB, Borch J, Hagen ML, Hass U, Christiansen S, Axelstad M, Kledal T, Dalgaard M, McKinnell C, Brokken LJ, Vinggaard AM: Mechanisms of action underlying the antiandrogenic effects of the fungicide prochloraz. Toxicol Appl Pharmacol. 2006 Jun 1;213(2):160-71. Epub 2006 Jan 10. Increased expression of P450c17 mRNA was observed in fetal male adrenals, and the androgen-regulated genes ornithine decarboxylase, prostatic binding protein C3 as well as insulin-like growth factor I mRNA were reduced in ventral prostates PND 16. |
2(0,0,0,2) | Details |
| 17234647 | Blystone CR, Furr J, Lambright CS, Howdeshell KL, Ryan BC, Wilson VS, Leblanc GA, Gray LE Jr: Prochloraz inhibits production at dosages below those that affect androgen-dependent organ weights or the onset of puberty in the male Sprague Dawley rat. Toxicol Sci. 2007 May;97(1):65-74. Epub 2007 Jan 18. The hormone results suggested that PCZ was inhibiting CYP17 activity. |
1(0,0,0,1) | Details |
| 18800561 | Zhang X, Hecker M, Tompsett AR, Park JW, Jones PD, Newsted J, Au D, Kong R, Wu RS, Giesy JP: Responses of the medaka HPG axis PCR array and reproduction to prochloraz and ketoconazole. Environ Sci Technol. 2008 Sep 1;42(17):6762-9. Exposure to PCZ caused a compensatory upregulation in cytochrome P450 c17alphahydroxylase, 17,20-lyase (CYP17) and aromatase (CYP19) expression in the ovary, while KTC did not. |
1(0,0,0,1) | Details |