Protein Information

Name mitogen activated protein kinase (protein family or complex)
Synonyms MAPK; mitogen activated protein kinase; mitogen activated protein kinases

Compound Information

Name procymidone
CAS 3-(3,5-dichlorophenyl)-1,5-dimethyl-3-azabicyclo[3.1.0]hexane-2,4-dione

Reference List

PubMed Abstract RScore(About this table)
15013820 Radice S, Fumagalli R, Chiesara E, Ferraris M, Frigerio S, Marabini L: Estrogenic activity of procymidone in rainbow trout (Oncorhynchus mykiss) hepatocytes: a possible mechanism of action. Chem Biol Interact. 2004 Mar 15;147(2):185-93.

In summary, the results of the study clearly support the idea that the estrogenic activity of procymidone in primary cultured trout hepatocytes is mediated by ROS production, and that this activity is similar to that of the ligand-independent ER activation involving MAPK.
112(1,2,2,2) Details
16310225 Radice S, Chiesara E, Frigerio S, Fumagalli R, Parolaro D, Rubino T, Marabini L: Estrogenic effect of procymidone through activation of MAPK in MCF-7 breast carcinoma cell line. Life Sci. 2006 May 1;78(23):2716-23. Epub 2005 Nov 28.
243(3,3,3,3) Details