| Name | estrogen receptor |
|---|---|
| Synonyms | ER; ERA; ER alpha; ERalpha; ESR; ESR 1; ESR1; ESRA… |
| Name | procymidone |
|---|---|
| CAS | 3-(3,5-dichlorophenyl)-1,5-dimethyl-3-azabicyclo[3.1.0]hexane-2,4-dione |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15013820 | Radice S, Fumagalli R, Chiesara E, Ferraris M, Frigerio S, Marabini L: Estrogenic activity of procymidone in rainbow trout (Oncorhynchus mykiss) hepatocytes: a possible mechanism of action. Chem Biol Interact. 2004 Mar 15;147(2):185-93. The cells were treated for 24 h with procymidone 150 microM (with 17beta- [E2] 20 microM as a positive control) combined with an estrogen receptor (ER) antagonist (tamoxifen 20 microM or ICI 182,780 1 microM) or, given the drug toxic action on the production of reactive species (ROS), a free radical scavenger 30 microM). |
31(0,1,1,1) | Details |
| 16876421 | Tamura H, Ishimoto Y, Fujikawa T, Aoyama H, Yoshikawa H, Akamatsu M: Structural basis for androgen receptor agonists and antagonists: interaction of SPEED 98-listed chemicals and related compounds with the androgen receptor based on an in vitro reporter gene assay and 3D-QSAR. Bioorg Med Chem. 2006 Nov 1;14(21):7160-74. Epub 2006 Jul 28. A significant CoMFA model with r (2)=0.825 and q (2)=0.332 was developed for AR antagonist activity of 35 pure antagonists excluding procymidone. As several ERalpha agonists such as diethylstilbestrol (DES) acted as AR antagonists, the surface area of the AR ligand-binding domain (LBD) was compared with that of the ERalpha-LBD based on their reported crystal structures to analyze how those ligands interact with LBDs. |
3(0,0,0,3) | Details |
| 16964405 | Rucinski M, Ziolkowska A, Hochol A, Pucher A, Macchi C, Belloni AS, Nussdorfer GG, Malendowicz LK: and stimulating effect on osteocalcin, but not osteonectin and collagen-1alpha gene expression in primary culture of rat calvarial osteoblast-like cells. Int J Mol Med. 2006 Oct;18(4):565-70. Evidence is available that some endocrine disruptors, acting as selective estrogen receptor modulators (SERMs), interfere with osteoblast differentiation and function. Therefore, we investigated whether 17beta- bisphenol-A (BSP), silymarin, procymidone, linurone and benzophenone-3 (BP3) modulate differentiation of rat calvarial osteoblast-like (ROB) cells in primary in vitro culture. |
1(0,0,0,1) | Details |
| 15951094 | Seidlova-Wuttke D, Jarry H, Christoffel J, Rimoldi G, Wuttke W: Effects of bisphenol-A (BPA), dibutylphtalate (DBP), benzophenone-2 (BP2), procymidone (Proc), and linurone (Lin) on fat tissue, a variety of hormones and metabolic parameters: a 3 months comparison with effects of (E2) in ovariectomized (ovx) rats. Toxicology. 2005 Sep 15;213(1-2):13-24. |
0(0,0,0,0) | Details |
| 16310225 | Radice S, Chiesara E, Frigerio S, Fumagalli R, Parolaro D, Rubino T, Marabini L: Estrogenic effect of procymidone through activation of MAPK in MCF-7 breast carcinoma cell line. Life Sci. 2006 May 1;78(23):2716-23. Epub 2005 Nov 28. |
0(0,0,0,0) | Details |