Protein Information

Name cytochrome c
Synonyms CYC; CYCS; Cytochrome C; HCS; Cytochrome Cs

Compound Information

Name cacodylic acid
CAS dimethylarsinic acid

Reference List

PubMed Abstract RScore(About this table)
2841331 Gopal D, Wilson GS, Earl RA, Cusanovich MA: Cytochrome c: ion binding and redox properties. J Biol Chem. 1988 Aug 25;263(24):11652-6.

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1651237 Whitford D, Concar DW, Williams RJ: The promotion of self-association of horse-heart cytochrome c by hexametaphosphate anions. Eur J Biochem. 1991 Aug 1;199(3):561-8.

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10021 Miller WG, Cusanovich MA: Electron transport by C-type cytochromes. Biophys Struct Mech. 1975 Feb 19;1(2):97-111.


The reaction of horse heart cytochrome c with anionic reductants..
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3019766 Concar DW, Hill HA, Moore GR, Whitford D, Williams RJ: The modulation of cytochrome c electron self-exchange by site-specific chemical modification and anion binding. FEBS Lett. 1986 Sep 29;206(1):15-9.

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7843134 Yamanaka K, Okada S: Induction of lung-specific DNA damage by metabolically methylated arsenics via the production of free radicals. Environ Health Perspect. 1994 Sep;102 Suppl 3:37-40.


Dimethylarsenic peroxyl radical [(CH3) 2AsOO.] and superoxide anion radical produced from the reaction between molecular oxygen and dimethylarsine were detected by electron-spin resonance analysis using a spin-trapping agent and the cytochrome-c method, respectively.
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19167414 Bae ON, Lim KM, Noh JY, Chung SM, Kim SH, Chung JH: Trivalent methylated arsenical-induced phosphatidylserine exposure and apoptosis in platelets may lead to increased thrombus formation. Toxicol Appl Pharmacol. 2009 Sep 1;239(2):144-53. Epub 2009 Jan 6.


In freshly isolated human platelets, treatment of MMA (III) resulted in phosphatidylserine (PS) exposure, a hallmark of procoagulant activation, accompanied by distinctive apoptotic features including mitochondrial membrane potential disruption, cytochrome c release, and caspase-3 activation.
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