Protein Information

Name catalase
Synonyms CAT; Catalase; Erythrocyte derived growth promoting factor; Carnitine O acetyltransferase; Carnitine acetylase; Carnitine acetyltransferase; CAT; Catalases…

Compound Information

Name cacodylic acid
CAS dimethylarsinic acid

Reference List

PubMed Abstract RScore(About this table)
7843134 Yamanaka K, Okada S: Induction of lung-specific DNA damage by metabolically methylated arsenics via the production of free radicals. Environ Health Perspect. 1994 Sep;102 Suppl 3:37-40.


An in vitro experiment indicated that DNA single-strand breaks by dimethylarsine were suppressed by the presence of superoxide dismutase and catalase, suggesting that the strand breaks were induced via the production of free-radical species including active oxygens.
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12076509 Ahmad S, Kitchin KT, Cullen WR: Plasmid DNA damage caused by methylated arsenicals, ascorbic acid and human liver ferritin. Toxicol Lett. 2002 Jul 7;133(1):47-57.


Addition of catalase (which can increase Fe (2+) concentrations) further increased the plasmid DNA damage.
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2017750 Yamanaka K, Hasegawa A, Sawamura R, Okada S: Cellular response to oxidative damage in lung induced by the administration of dimethylarsinic acid, a major metabolite of inorganic arsenics, in mice. Toxicol Appl Pharmacol. 1991 Apr;108(2):205-13.


In male ICR mice given a single po dose (1500 mg/kg) of DMAA-Na, the activities of mitochondrial superoxide dismutase, glutathione peroxidase, and glucose-6-phosphate dehydrogenase significantly increased at 6 hr or longer after dosing, while cytosolic superoxide dismutase and catalase did not.
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2484622 Yamanaka K, Hasegawa A, Sawamura R, Okada S: DNA strand breaks in mammalian tissues induced by methylarsenics. Biol Trace Elem Res. 1989 Jul-Sep;21:413-7.


Furthermore, the strand breaks after exposure to dimethylarsine were reduced in the presence of catalase and/or superoxide dismutase.
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