| Name | glutathione S transferase |
|---|---|
| Synonyms | GST class alpha 2; Gst2; GST class alpha; GST class alpha member 2; GST gamma; GSTA 2; GSTA2; GSTA2 2… |
| Name | cacodylic acid |
|---|---|
| CAS | dimethylarsinic acid |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16531839 | Marcos R, Martinez V, Hernandez A, Creus A, Sekaran C, Tokunaga H, Quinteros D: Metabolic profile in workers occupationally exposed to arsenic: role of GST polymorphisms. J Occup Environ Med. 2006 Mar;48(3):334-41. With respect to the role of different genetic polymorphisms in the glutathione S-transferase (GST) genes in the modulation of the urinary profiles, for the overall population only a tendency was just observed between GSTM1 null and MMA excretion as well as between GSTP1 val/val and DMA excretion. |
1(0,0,0,1) | Details |
| 7882321 | Yamamoto S, Konishi Y, Matsuda T, Murai T, Shibata MA, Matsui-Yuasa I, Otani S, Kuroda K, Endo G, Fukushima S: Cancer induction by an organic arsenic compound, dimethylarsinic acid (cacodylic acid), in F344/DuCrj rats after pretreatment with five carcinogens. Cancer Res. 1995 Mar 15;55(6):1271-6. Induction of preneoplastic lesions (glutathione S-transferase placental form-positive foci in the liver and atypical tubules in the kidney) was also significantly increased in DMA-treated groups. |
1(0,0,0,1) | Details |
| 12018983 | Sakurai T, Qu W, Sakurai MH, Waalkes MP: A major human arsenic metabolite, dimethylarsinic acid, requires to induce apoptosis. Chem Res Toxicol. 2002 May;15(5):629-37. Ethacrynic acid (EA), an inhibitor of glutathione S-transferase (GST) that catalyzes GSH-substrate conjugation, acivicin, an inhibitor of gamma-glutamyltranspeptidase (GGT) which catalyzes the initial breakdown of GSH-substrate conjugates, and aminooxyacetic acid (AOAA), an inhibitor of beta-lyase which catalyzes the final breakdown of GSH-substrate conjugates, all were effective in suppressing DMA-induced apoptosis. |
1(0,0,0,1) | Details |
| 15276415 | Sakurai T, Ochiai M, Kojima C, Ohta T, Sakurai MH, Takada NO, Qu W, Waalkes MP, Fujiwara K: Role of in dimethylarsinic acid-induced apoptosis. Toxicol Appl Pharmacol. 2004 Aug 1;198(3):354-65. DMAs (V) exposure temporarily decreased cellular (GSH) levels and enhanced cellular glutathione S-transferase (GST) activity from 6 h after the exposure when the cells were still alive. |
1(0,0,0,1) | Details |
| 12115560 | Nishikawa T, Wanibuchi H, Ogawa M, Kinoshita A, Morimura K, Hiroi T, Funae Y, Kishida H, Nakae D, Fukushima S: Promoting effects of monomethylarsonic acid, dimethylarsinic acid and trimethylarsine oxide on induction of rat liver preneoplastic glutathione S-transferase placental form positive foci: a possible reactive species mechanism. Int J Cancer. 2002 Jul 10;100(2):136-9. |
2(0,0,0,2) | Details |
| 17548696 | Ahsan H, Chen Y, Kibriya MG, Slavkovich V, Parvez F, Jasmine F, Gamble MV, Graziano JH: Arsenic metabolism, genetic susceptibility, and risk of premalignant skin lesions in Bangladesh. Cancer Epidemiol Biomarkers Prev. 2007 Jun;16(6):1270-8. Adjusted odds ratios (OR) for skin lesions were estimated in relation to the polymorphisms in the glutathione S-transferase omega1 and methylenetetrahydrofolate reductase genes, the percentage of monomethylarsonous acid (%MMA) and dimethylarsinic acid (%DMA) in urine, and the ratios of MMA to inorganic arsenic and DMA to MMA. |
2(0,0,0,2) | Details |
| 9473732 | Wanibuchi H, Hori T, Meenakshi V, Ichihara T, Yamamoto S, Yano Y, Otani S, Nakae D, Konishi Y, Fukushima S: Promotion of rat hepatocarcinogenesis by dimethylarsinic acid: association with elevated ornithine decarboxylase activity and formation of in the liver. Jpn J Cancer Res. 1997 Dec;88(12):1149-54. In experiment 1, glutathione-S-transferase placental form (GST-P)-positive foci, putative preneoplastic lesions, were employed as endpoints of a liver medium-term bioassay for carcinogens (Ito test). |
1(0,0,0,1) | Details |