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Yamanaka K, Hayashi H, Kato K, Hasegawa A, Oku N, Okada S: DNA single-strand breaks in L-132 cells resulting from inhibition of repair polymerization shortly after exposure to dimethylarsinic acid. Biol Pharm Bull. 1997 Feb;20(2):163-7.
The strand breaks were detected by an alkaline elution method with the use of inhibitors of DNA polymerase, aphidicolin (aph) and 2',3'-dideoxythymidine (ddT); the former inhibits DNA polymerases alpha, delta and epsilon, and the latter inhibits DNA polymerase beta. |
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