Protein Information

Name p50
Synonyms ARHGEF 7; PAK3; p85; p50; ARHGEF7; BETA PIX; COOL 1; COOL1…

Compound Information

Name propanil
CAS

Reference List

PubMed Abstract RScore(About this table)
11312646 Frost LL, Neeley YX, Schafer R, Gibson LF, Barnett JB: Propanil inhibits tumor necrosis factor-alpha production by reducing nuclear levels of the transcription factor nuclear factor-kappab in the macrophage cell line ic-21. Toxicol Appl Pharmacol. 2001 May 1;172(3):186-93.

The marked reduction in nuclear p65/p50 NF-kappaB levels and diminished binding to the TNF-alpha promoter in propanil-treated cells are consistent with reduced TNF-alpha levels induced by LPS.
112(1,2,2,2) Details