Protein Information

Name cytochrome P450 monooxygenase
Synonyms CYP M; CYP20A1; CYP20A1 protein; Cytochrome P450 family 20 subfamily A polypeptide 1; Cytochrome P450 monooxygenase; CYP20A1 proteins; Cytochrome P450 family 20 subfamily A polypeptide 1s; Cytochrome P450 monooxygenases

Compound Information

Name propoxur
CAS

Reference List

PubMed Abstract RScore(About this table)
11681686 Sanchez-Arroyo H, Koehler PG, Valles SM: Effects of the synergists piperonyl butoxide and S,S,S-tributyl phosphorotrithioate on propoxur pharmacokinetics in Blattella germanica (Blattodea: Blattellidae). J Econ Entomol. 2001 Oct;94(5):1209-16.

Treatment of adult male German cockroaches with the cytochrome P450 monooxygenase inhibitor, PBO, or the esterase inhibitor, DEF, increased propoxur toxicity by 2- and 6.8-fold, respectively, implicating hydrolysis as a major detoxification route of propoxur in the German cockroach.
32(0,1,1,2) Details
19419775 Riaz MA, Poupardin R, Reynaud S, Strode C, Ranson H, David JP: Impact of glyphosate and benzo [a] pyrene on the tolerance of mosquito larvae to chemical insecticides. Aquat Toxicol. 2009 Jun 4;93(1):61-9. Epub 2009 Mar 31.

The effect of exposure of Aedes aegypti larvae for 72h to sub-lethal concentrations of the herbicide glyphosate and the polycyclic aromatic hydrocarbon benzo [a] pyrene on their subsequent tolerance to the chemical insecticides imidacloprid, permethrin and propoxur, detoxification enzyme activities and transcription of detoxification genes was investigated.
Cytochrome P450 monooxygenases activities were strongly induced in larvae exposed to benzo [a] pyrene and moderately induced in larvae exposed to imidacloprid and glyphosate.
1(0,0,0,1) Details