Protein Information

Name Acetylcholinesterase
Synonyms ACHE; ACHE protein; AChE; ARACHE; AcChoEase; Acetylcholine acetylhydrolase; Acetylcholinesterase; Acetylcholinesterase isoform E4 E6 variant…

Compound Information

Name prothiofos
CAS

Reference List

PubMed Abstract RScore(About this table)
17196934 Lee DW, Choi JY, Kim WT, Je YH, Song JT, Chung BK, Boo KS, Koh YH: Mutations of acetylcholinesterase1 contribute to prothiofos-resistance in Plutella xylostella (L.). Biochem Biophys Res Commun. 2007 Feb 16;353(3):591-7. Epub 2006 Dec 21.

In vitro functional expression of AChEs in Sf9 cells revealed that only resistant AChE1 is less inhibited with paraoxon, suggesting that resistant AChE1 is responsible for prothiofos-resistance.
34(0,1,1,4) Details
19737786 Eddleston M, Worek F, Eyer P, Thiermann H, Von Meyer L, Jeganathan K, Sheriff MH, Dawson AH, Buckley NA: Poisoning with the S-Alkyl organophosphorus insecticides profenofos and prothiofos. QJM. 2009 Nov;102(11):785-92. Epub 2009 Sep 8.

This chemical structure affects their responsiveness to oxime-induced acetylcholinesterase (AChE) reactivation after poisoning.
1(0,0,0,1) Details