| Name | CYP3A4 |
|---|---|
| Synonyms | CP33; CYP3; HLP; CYP3A; CP34; CYP 3A4; CYP 3; CYP3A3… |
| Name | pyrethrins |
|---|---|
| CAS | pyrethrins |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18022748 | Price RJ, Giddings AM, Scott MP, Walters DG, Capen CC, Osimitz TG, Lake BG: Effect of Pyrethrins on cytochrome P450 forms in cultured rat and human hepatocytes. Toxicology. 2008 Jan 14;243(1-2):84-95. Epub 2007 Oct 7. Pyrethrins and Phenobarbital also induced CYP3A-dependent 6beta-hydroxylase activity in rat hepatocytes. |
18(0,0,3,3) | Details |
| 19249324 | Yang D, Wang X, Chen YT, Deng R, Yan B: Pyrethroid insecticides: isoform-dependent hydrolysis, induction of cytochrome P450 3A4 and evidence on the involvement of the pregnane X receptor. Toxicol Appl Pharmacol. 2009 May 15;237(1):49-58. Epub 2009 Feb 26. |
4(0,0,0,4) | Details |
| 19326768 | Das PC, Streit TM, Cao Y, Rose RL, Cherrington N, Ross MK, Wallace AD, Hodgson E: Pyrethroids: cytotoxicity and induction of CYP isoforms in human hepatocytes. Drug Metabol Drug Interact. 2008;23(3-4):211-36. At 100 microM deltamethrin 2-3 fold induction of CYP1A1 and CYP2B6 mRNA was observed, while at the same time an approximately 25-fold induction of CYP3A4 was noted. |
2(0,0,0,2) | Details |
| 18948380 | Scollon EJ, Starr JM, Godin SJ, DeVito MJ, Hughes MF: In vitro metabolism of pyrethroid pesticides by rat and human hepatic microsomes and cytochrome p450 isoforms. Drug Metab Dispos. 2009 Jan;37(1):221-8. Epub 2008 Oct 23. Human P450 isoforms that showed activity toward multiple pyrethroids were CYP2C8, CYP2C9, CYP2C19, and CYP3A4. |
1(0,0,0,1) | Details |
| 17188729 | Price RJ, Walters DG, Finch JM, Gabriel KL, Capen CC, Osimitz TG, Lake BG: A mode of action for induction of liver tumors by Pyrethrins in the rat. Toxicol Appl Pharmacol. 2007 Jan 15;218(2):186-95. Epub 2006 Nov 11. Significant increases were also observed in CYP3A-dependent 6beta-hydroxylase activity. |
1(0,0,0,1) | Details |