Protein Information

Name alkaline phosphatase
Synonyms ALP 1; Alkaline phosphatase; ALPG; ALPPL; ALPPL 2; ALPPL2; GCAP; Germ cell alkaline phosphatase…

Compound Information

Name pyrethrins
CAS pyrethrins

Reference List

PubMed Abstract RScore(About this table)
15204980 Garg UK, Pal AK, Jha GJ, Jadhao SB: Pathophysiological effects of chronic toxicity with synthetic pyrethroid, organophosphate and chlorinated pesticides on bone health of broiler chicks. Toxicol Pathol. 2004 May-Jun;32(3):364-9.


However, increase an (p < 0.01) in serum alkaline phosphatase activity was noted and serum total protein decreased (p < 0.01) in all treated groups.
1(0,0,0,1) Details
12716053 el-Demerdash FM, Yousef MI, Al-Salhen KS: Protective effects of isoflavone on some biochemical parameters affected by cypermethrin in male rabbits. J Environ Sci Health B. 2003 May;38(3):365-78.


The activities of glutathione S-transferase (GST) (liver, brain and testes), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) (liver and testes), and alkaline phosphatase (AlP) (liver) were significantly (P < 0.05) decreased due to cypermethrin administration.
1(0,0,0,1) Details
16326432 Kim IY, Han SY, Kang TS, Lee BM, Choi KS, Moon HJ, Kim TS, Kang IH, Kwack SJ, Moon A, Ahn MY, Kim HS: Pyrethroid insecticides, fenvalerate and permethrin, inhibit progesterone-induced alkaline phosphatase activity in T47D human breast cancer cells. J Toxicol Environ Health A. 2005 Dec 10;68(23-24):2175-86.

2(0,0,0,2) Details
17640710 Borges A, Scotti LV, Siqueira DR, Zanini R, Amaral F, Jurinitz DF, Wassermann GF: Changes in hematological and serum biochemical values in jundia Rhamdia quelen due to sub-lethal toxicity of cypermethrin. Chemosphere. 2007 Oct;69(6):920-6. Epub 2007 Jul 20.


The 30% LC (50), 0.08 ppm, produced significant increases in Mg (2+), P, K (+), creatinine, urea, glucose, cholesterol, aspartate aminotransferase and alkaline phosphatase levels, and reduction in total proteins and triglycerides in serum.
2(0,0,0,2) Details
16459564 Singh VK, Dixit P, Saxena PN: Cybil induced hepatobiochemical changes in wistar rats. J Environ Biol. 2005 Oct;26(4):725-7.


When compared with the control values, both the doses enhanced the level of glycogen, cholesterol, total lipid and acid phosphatase activities, while decreased activity of alkaline phosphatase.
2(0,0,0,2) Details
20218522 Dahamna S, Harzallah D, Guemache A, Sekfali N: Biochemical investigation of cypermethrin toxicity in rabbits. Commun Agric Appl Biol Sci. 2009;74(1):149-53.

An increase, in the plasma enzyme activity in Alkaline phosphatase, related to their role in the cell permeability.
Pyrethroids are often combined commercially with other chemicals called synergists, which enhance the insecticidal activity of the pyrethrins and pyrethroids.
1(0,0,0,1) Details
12524023 Das BK, Mukherjee SC: Toxicity of cypermethrin in Labeo rohita fingerlings: biochemical, enzymatic and haematological consequences. Comp Biochem Physiol C Toxicol Pharmacol. 2003 Jan;134(1):109-21.


Acid phosphatase was unchanged while alkaline phosphatase was depleted.
1(0,0,0,1) Details
15365239 Manna S, Bhattacharyya D, Mandal TK, Das S: Repeated dose toxicity of alfa-cypermethrin in rats. J Vet Sci. 2004 Sep;5(3):241-5.


It increased the serum aminotransaminases (AST, ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH) activities and blood glucose level significantly. alpha-CP decreased RBC count, PCV and Hb level significantly.
1(0,0,0,1) Details
16466792 Vijayavel K, Balasubramanian MP: Interaction of potash and decis in the ecophysiology of a freshwater fish Oreochromis mossambicus. Ecotoxicol Environ Saf. 2007 Feb;66(2):154-8. Epub 2006 Feb 8.


The marker enzymes (acid phosphatase, alkaline phosphatase, aspartate transaminase, alanine transaminase) were also analyzed in blood, liver and muscle.
1(0,0,0,1) Details
18946182 Eraslan G, Kanbur M, Silici S, Altinordulu S, Karabacak M: Effecs of cypermethrin on some biochemical changes in rats: the protective role of propolis. Exp Anim. 2008 Oct;57(5):453-60.


Serum glucose, triglyceride, uric acid, cholesterol, aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) activities/levels, plasma and tissue malondialdehyde (MDA) levels, and erythrocyte and tissue superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) activities were determined.
1(0,0,0,1) Details
19084261 Saha S, Kaviraj A: Effects of cypermethrin on some biochemical parameters and its amelioration through dietary supplementation of ascorbic acid in freshwater catfish Heteropneustes fossilis. Chemosphere. 2009 Mar;74(9):1254-9. Epub 2008 Dec 11.


Acid and alkaline phosphatase activities of liver and ascorbic acid level of blood, liver and kidney also decreased significantly in H. fossilis exposed to cypermethrin as compared with control.
1(0,0,0,1) Details
11862614 Mani U, Islam F, Prasad AK, Kumar P, Maji BK, Dutta KK: Pulmonary toxicity of a formulated preparation of fenvalerate in rats subchronically exposed by nose only inhalation for 90 days. Biomed Environ Sci. 2001 Dec;14(4):333-40.


RESULTS: Fen exposed rats showed a significant increase in enzymatic activities of lactate dehydrogenase (LDH), acid phosphatase (ACP), alkaline phosphatase (ALP) and gamma-glutamyl transferase (gamma-GT) which are considered as biochemical indicators of pulmonary damage.
1(0,0,0,1) Details
17159788 Dobsikova R, Velisek J, Wlasow T, Gomulka P, Svobodova Z, Novotny L: Effects of cypermethrin on some haematological, biochemical and histopathological parameters of common carp (Cyprinus carpio L.). Neuro Endocrinol Lett. 2006 Dec;27 Suppl 2:91-5.


As far as biochemical indices are concerned, the exposure caused a significant (P <0.01) increase in glucose and lactate concentration and creatine kinase activity, and a significant (P <0.01) decrease in total proteins, albumins, total globulins, ammonia, lactate dehydrogenase and alkaline phosphatase in blood plasma of exposed carp compared to the control group.
1(0,0,0,1) Details