Protein Information

Name glutathione reductase
Synonyms GLUR; GR; GRD 1; GRD1; GRase; GSR; Glutathione reductase; GRases…

Compound Information

Name pyrethrins
CAS pyrethrins

Reference List

PubMed Abstract RScore(About this table)
17055627 Bashir F, Mahmooduzzafar, Siddiqi TO, Iqbal M: The antioxidative response system in Glycine max (L.) Merr. exposed to Deltamethrin, a synthetic pyrethroid insecticide. Environ Pollut. 2007 May;147(1):94-100. Epub 2006 Oct 19.


Among the enzymatic antioxidants, activity of superoxide dismutase, ascorbate peroxidase and glutathione reductase increased significantly whereas that of catalase declined markedly in relation to increasing concentration of Deltamethrin applied.
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15892188 Prasanthi K, Muralidhara, Rajini PS: Morphological and biochemical perturbations in rat erythrocytes following in vitro exposure to Fenvalerate and its metabolite. Toxicol In Vitro. 2005 Jun;19(4):449-56.


At higher concentrations, significant decreases in the activities of vital antioxidant enzymes viz., catalase, superoxide dismutase, glutathione transferase and glutathione reductase were also discernible clearly suggesting the potency of both, parent compound and its metabolite to induce oxidative stress in erythrocytes.
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15339126 Amer M, Metwalli M, Abu el-Magd Y: Skin diseases and enzymatic antioxidant activity among workers exposed to pesticides. East Mediterr Health J. 2002 Mar-May;8(2-3):363-73.


Activity of the antioxidant enzymes superoxide dismutase, glutathione peroxidase and glutathione reductase was also evaluated.
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15266958 Jayasree U, Reddy AG, Reddy KS, Anjaneyulu Y, Kalakumar B: Evaluation of vitamin E against deltamethrin toxicity in broiler chicks. Indian J Physiol Pharmacol. 2003 Oct;47(4):447-52.


Weekly body weights, feed conversion ratio, glutathione (GSH) concentration and high density lipoproteins (HDL) were significantly (P < 0.05) reduced, while the activities of glutathione peroxidase (GSH-Px), glutathione reductase (GSH-R), catalase, aspartate aminotransferase (AST) and lactate dehydrogenase (LDH), and the lipid profile and renal biomarkers were increased significantly (P < 0.05) in group 2 and 3 at the end of 4th wk as compared to group 1.
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16737586 Li HY, Shi N, Dai ZH, Zhong YF, Wu SY: [Effects of deltamethrin on gene expression of some antioxidase, gamma glutamylcysteine synthetase and NFE2 related factor 2 (Nrf2) in brain tissue]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2006 May;24(5):273-7.


OBJECTIVE: To study the effects of deltamethrin (DM) on the mRNA expression of copper-zinc dependent SOD (CuZn-SOD), glutathione reductase (GR) and gamma glutamylcysteine synthetase (gamma-GCS) light subunit (GCSl), as well as on expression of both mRNA and protein of gamma-GCS heavy subunit (GCSh) and NFE2 related factor 2 (Nrf2) in cerebral cortex and hippocampus of rats.
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16001157 Atif F, Parvez S, Pandey S, Ali M, Kaur M, Rehman H, Khan HA, Raisuddin S: Modulatory effect of cadmium exposure on deltamethrin-induced oxidative stress in Channa punctata Bloch. Arch Environ Contam Toxicol. 2005 Oct;49(3):371-7. Epub 2005 Jul 6.


Activities of glutathione peroxidase, glutathione reductase, and glutathione-S-transferase were also studied in liver, kidney, and gills.
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16105448 Li HY, Shi N, Chen D, Dai ZH, Lu WH, Wang B, Li YR: [Oxidative stress of deltamethrin on rat nervous system] . Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2005 Apr;23(2):97-101.


The content of malondialdehyde (MDA) and the activity of total-superoxide dismutase (T-SOD, including Mn-SOD and CuZn-SOD), catalase (CAT), glutathione-S-transferase (GST), glutathione peroxidase (GSH-Px) and glutathione reductase (GR) in cerebral cortex and hippocampus tissue were determined.
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