Protein Information

Name gamma glutamylcysteine synthetase
Synonyms GCLM; GCS light chain; GLCLR; Gamma ECS; Gamma glutamylcysteine synthetase; Gamma glutamylcysteine synthetase regulatory subunit; Glutamate cysteine ligase modifier subunit; Glutamate cysteine ligase regulatory subunit…

Compound Information

Name pyrethrins
CAS pyrethrins

Reference List

PubMed Abstract RScore(About this table)
16737586 Li HY, Shi N, Dai ZH, Zhong YF, Wu SY: [Effects of deltamethrin on gene expression of some antioxidase, gamma glutamylcysteine synthetase and NFE2 related factor 2 (Nrf2) in brain tissue]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2006 May;24(5):273-7.

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17540521 Li HY, Wu SY, Shi N: Transcription factor Nrf2 activation by deltamethrin in PC12 cells: Involvement of ROS. Toxicol Lett. 2007 Jun 15;171(1-2):87-98. Epub 2007 Apr 27.


In addition, DM exposure caused nuclear accumulation of Nrf2 in association with downstream activation of Nrf2-mediated oxidative response genes, such as heme oxygenase-l (HO-1) and gamma-glutamylcysteine synthetase catalytic heavy subunit (GCSh).
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16105448 Li HY, Shi N, Chen D, Dai ZH, Lu WH, Wang B, Li YR: [Oxidative stress of deltamethrin on rat nervous system] . Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2005 Apr;23(2):97-101.


The reduced glutathione (GSH) content and gamma-glutamylcysteine synthetase (gamma-GCS) activity in cytosolic fraction of cerebral cortex and hippocampus tissue was determined by reversed-phase high performance liquid chromatographic assay with o-phthalaldehyde pre-column derivation.
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