Protein Information

Name tyrosine hydroxylase
Synonyms Putative tyrosine hydroxylase variant; TH; TH protein; TYH; Truncated tyrosine hydroxylase; Tyrosine 3 hydroxylase; Tyrosine 3 monooxygenase; Tyrosine hydroxylase…

Compound Information

Name pyrethrins
CAS pyrethrins

Reference List

PubMed Abstract RScore(About this table)
16673815 Liu GP, Ma Q, Shi N: Tyrosine hydroxylase as a target for deltamethrin in the nigrostriatal dopaminergic pathway. Biomed Environ Sci. 2006 Feb;19(1):27-34.

5(0,0,0,5) Details
15461254 Liu G, Shi N, Ma R: [Effects of pyrethroids on tyrosine hydroxylase in nigrostriatum of male rats]. Wei Sheng Yan Jiu. 2004 Jul;33(4):390-3.

4(0,0,0,4) Details
16229977 Liu GP, Shi N: The inhibitory effects of deltamethrin on dopamine biosynthesis in rat PC12 cells. Toxicol Lett. 2006 Mar 1;161(3):195-9. Epub 2005 Oct 17.


Flow cytometry (FCM) and RT-PCR technology were used to detect the levels of tyrosine hydroxylase (TH) mRNA and protein in PC12 cells treated with different doses of deltamethrin for 3 h or 12 h.
2(0,0,0,2) Details
15555315 Liu GP, Shi N, Liang JH, Chen L: [Effects of pyrethroids on dopamine and its metabolites in nigrostriatum of male rats.]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2004 Oct;22(5):368-70.


CONCLUSION: DM may inhibit tyrosine hydroxylase and decrease the level of DA in striatum, and both pyrethroid pesticides may increase the metabolism of dopamine in striatum.
1(0,0,0,1) Details