Protein Information

Name glucose 6 phosphate dehydrogenase
Synonyms 6 phosphogluconolactonase; GDH; G6PDH; Glucose 6 phosphate dehydrogenase; GDH/6PGL endoplasmic bifunctional protein; GDH/6PGL endoplasmic bifunctional protein precursor; Glucose 1 dehydrogenase; Glucose dehydrogenase…

Compound Information

Name pyrethrins
CAS pyrethrins

Reference List

PubMed Abstract RScore(About this table)
11802603 Kamalaveni K, Gopal V, Sampson U, Aruna D: Effect of pyrethroids on carbohydrate metabolic pathways in common carp, Cyprinus carpio. Pest Manag Sci. 2001 Dec;57(12):1151-4.


The activity levels of succinate dehydrogenase (SDH) and glucose-6-phosphate dehydrogenase (G6PD) were assessed in various tissues of Cyprinus carpio var communis which had been exposed to lethal concentrations of group-II pyrethroids (deltamethrin, cypermethrin, fenvalerate and fluvalinate) for a period of 72 h.
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19225809 Jagadeshwaran U, Vijayan VA: Biochemical characterization of deltamethrin resistance in a laboratory-selected strain of Aedes aegypti. Parasitol Res. 2009 Jun;104(6):1431-8. Epub 2009 Feb 19.


Significant elevation in the activity of alpha- and beta-esterases, glucose-6-phosphate dehydrogenase (G6PD), CYTP450 (CYTP450), and glutathione-s-transferase (GST) were noticed in DR.
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15313449 Tripathi G, Verma P: Fenvalerate-induced changes in a catfish, Clarias batrachus: metabolic enzymes, RNA and protein. Comp Biochem Physiol C Toxicol Pharmacol. 2004 May;138(1):75-9.


Exposure to fenvalerate gradually decreased the activity of citrate synthase (CS), glucose 6-phosphate dehydrogenase (G6-PDH) and lactate dehydrogenase (LDH) in brain, liver and skeletal muscle up to 21 days.
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12622206 Ganesh KN, Vijayan VA, Urmila J, Gopalan N, Prakash S: Role of esterases and monooxygenase in the deltamethrin resistance in Anopheles stephensi Giles (1908), at Mysore. Indian J Exp Biol. 2002 May;40(5):583-8.


The reason for this kind of resistance was analyzed on the basis of differential activity of A-esterase, B-esterase, glutathione s-transferase (GST) and glucose 6-phosphate dehydrogenase (G6PD).
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12866824 Ganesh KN, Urmila J, Vijayan VA: Pyrethroid susceptibility & enzyme activity in two malaria vectors, Anopheles stephensi (Liston) &. Indian J Med Res. 2003 Jan;117:30-8.


An attempt was also made to correlate the activities of certain detoxifying enzymes such as A- esterase, B-esterase, glutathione-S transferase (GST) and glucose-6-phosphate dehydrogenase (G6PD) with the tolerance levels of the two vectors.
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12507254 Mani U, Islam F, Prasad AK, Kumar P, Suresh Kumar V, Maji BK, Dutta KK: Steroidogenic alterations in testes and sera of rats exposed to formulated Fenvalerate by inhalation. Hum Exp Toxicol. 2002 Nov;21(11):593-7.


The results indicate significant reduction in the weight of testes, epididymal sperm counts, and sperm motility, along with decrease in marker testicular enzymes for testosterone biosynthesis viz. 17-beta-hydroxy steroid dehydrogenase (17-beta-HSD) and glucose-6-phosphate dehydrogenase (G6PDH), leading to net decrease in serum testosterone concentration in group of rats exposed to one-fifth LC50 of Fen (20% EC) by inhalation (4 hours/day, five days a week) subchronically for three months.
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