| Name | hCE 1 |
|---|---|
| Synonyms | CAP1A; HCAP 1; HCAP1; HCE; HCE 1; HCE1; Human capping enzyme 1; RNA Guanylyl Transferase and 5 prime Phosphatase… |
| Name | pyrethrins |
|---|---|
| CAS | pyrethrins |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18983829 | Yang D, Pearce RE, Wang X, Gaedigk R, Wan YJ, Yan B: Human carboxylesterases HCE1 and HCE2: ontogenic expression, inter-individual variability and differential hydrolysis of oseltamivir, deltamethrin and permethrin. Biochem Pharmacol. 2009 Jan 15;77(2):238-47. Epub 2008 Oct 15. |
3(0,0,0,3) | Details |
| 16387282 | Ross MK, Borazjani A, Edwards CC, Potter PM: Hydrolytic metabolism of pyrethroids by human and other mammalian carboxylesterases. Biochem Pharmacol. 2006 Feb 28;71(5):657-69. Epub 2006 Jan 4. Pure human CEs (hCE-1 and hCE-2), a rabbit CE (rCE), and two rat CEs (Hydrolases A and B) were used to study the hydrolytic metabolism of the following pyrethroids: 1Rtrans-resmethrin (bioresmethrin), 1RStrans-permethrin, and 1RScis-permethrin. hCE-1 and hCE-2 hydrolyzed trans-permethrin 8- and 28-fold more efficiently than cis-permethrin (when k (cat)/K (m) values were compared), respectively. |
3(0,0,0,3) | Details |
| 16855054 | Godin SJ, Scollon EJ, Hughes MF, Potter PM, DeVito MJ, Ross MK: Species differences in the in vitro metabolism of deltamethrin and esfenvalerate: differential oxidative and hydrolytic metabolism by humans and rats. Drug Metab Dispos. 2006 Oct;34(10):1764-71. Epub 2006 Jul 19. Results of CE metabolism revealed that human carboxylesterase 1 (hCE-1) was markedly more active toward deltamethrin than the class 1 rat CEs hydrolase A and B and the class 2 human CE (hCE-2); however, hydrolase A metabolized esfenvalerate 2-fold faster than hCE-1, whereas hydrolase B and hCE-1 hydrolyzed esfenvalerate at equal rates. |
1(0,0,0,1) | Details |
| 19249324 | Yang D, Wang X, Chen YT, Deng R, Yan B: Pyrethroid insecticides: isoform-dependent hydrolysis, induction of cytochrome P450 3A4 and evidence on the involvement of the pregnane X receptor. Toxicol Appl Pharmacol. 2009 May 15;237(1):49-58. Epub 2009 Feb 26. Some pyrethroids such as bioresmethrin were preferably hydrolyzed by carboxylesterase HCE1, whereas others such as bifenthrin preferably by HCE2. |
1(0,0,0,1) | Details |
| 16359636 | Nishi K, Huang H, Kamita SG, Kim IH, Morisseau C, Hammock BD: Characterization of pyrethroid hydrolysis by the human liver carboxylesterases hCE-1 and hCE-2. Arch Biochem Biophys. 2006 Jan 1;445(1):115-23. |
4(0,0,0,4) | Details |