Protein Information

Name estrogen receptor
Synonyms ER; ERA; ER alpha; ERalpha; ESR; ESR 1; ESR1; ESRA…

Compound Information

Name pyrethrins
CAS pyrethrins

Reference List

PubMed Abstract RScore(About this table)
16395479 McCarthy AR, Thomson BM, Shaw IC, Abell AD: Estrogenicity of pyrethroid insecticide metabolites. . J Environ Monit. 2006 Jan;8(1):197-202. Epub 2005 Dec 14.


There is concern that insecticides are able to mimic the action of 17beta-estradiol by interaction with the human estrogen receptor.
3(0,0,0,3) Details
15799245 Chen R, Li A, Zhu T, Li C, Liu Q, Chang HC, Zhou J: JWA--a novel environmental-responsive gene, involved in estrogen receptor-associated signal pathway in MCF-7 and MDA-MB-231 breast carcinoma cells. J Toxicol Environ Health A. 2005 Mar 26;68(6):445-56.

2(0,0,0,2) Details
18419197 Zhao M, Zhang Y, Liu W, Xu C, Wang L, Gan J: Estrogenic activity of lambda-cyhalothrin in the MCF-7 human breast carcinoma cell line. Environ Toxicol Chem. 2008 May;27(5):1194-200.


The cell proliferation induced by LCT could be blocked completely, however, by the addition of 10 (-9) M of the estrogen receptor (ER)-antagonist ICI 182,780.
2(0,0,0,2) Details
12396874 Chen H, Xiao J, Hu G, Zhou J, Xiao H, Wang X: Estrogenicity of organophosphorus and pyrethroid pesticides. J Toxicol Environ Health A. 2002 Oct 11;65(19):1419-35.


The present study was undertaken to evaluate the estrogenic activities of nine pesticides (phoxim, malathion, monocrotophos, dimethoate, opunal, fenvalerate, cypermethrin, permethrin, and deltamethrin) using three in vitro methods [E-Screen assay, estrogen receptor (ER) competitive binding assay, and pS2 expression assay].
1(0,0,0,1) Details
19853000 Laffin B, Chavez M, Pine M: The pyrethroid metabolites 3-phenoxybenzoic acid and 3-phenoxybenzyl alcohol do not exhibit estrogenic activity in the MCF-7 human breast carcinoma cell line or Sprague-Dawley rats. Toxicology. 2010 Jan 12;267(1-3):39-44. Epub 2009 Oct 21.


Interestingly, the chemical structure of specific pyrethroid metabolites indicates that they may be more likely to interact with the estrogen receptor than the parent compounds.
1(0,0,0,1) Details
16326440 Kim SS, Kwack SJ, Lee RD, Lim KJ, Rhee GS, Seok JH, Kim BH, Won YH, Lee GS, Jeung EB, Lee BM, Park KL: Assessment of estrogenic and androgenic activities of tetramethrin in vitro and in vivo assays. J Toxicol Environ Health A. 2005 Dec 10;68(23-24):2277-89.


Estrogen receptor (ERalpha and ERbeta) protein levels were also measured in tetramethrin-treated rat uteri.
1(0,0,0,1) Details
15033010 Chen L, Shi N, Dong J, Li T, Chen D: [Effects of estradiol on deltamethrin-induced neurotoxicity in rat cerebro-cortical synaptosomes]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2004 Feb;22(1):22-5.


Meanwhile, the estrogen receptor (ER) antagonist, tamoxifen, was used to investigate the effect on estradiol.
1(0,0,0,1) Details
14583418 Brody SA, Loriaux DL: Epidemic of gynecomastia among haitian refugees: exposure to an environmental antiandrogen. Endocr Pract. 2003 Sep-Oct;9(5):370-5.


None of these substances bound to cytosol estrogen receptors.
1(0,0,0,1) Details
17937291 Wang L, Liu W, Yang C, Pan Z, Gan J, Xu C, Zhao M, Schlenk D: Enantioselectivity in estrogenic potential and uptake of bifenthrin. Environ Sci Technol. 2007 Sep 1;41(17):6124-8.


The cell proliferation induced by the two BF enantiomers may be through the classical estrogen response pathway via the estrogen receptor (ER), as the proliferation induced by the enantiomers could be completely blocked when combined with 10-6 mol/L of the ER antagonist ICI 182,780.
1(0,0,0,1) Details
12052007 Kunimatsu T, Yamada T, Ose K, Sunami O, Kamita Y, Okuno Y, Seki T, Nakatsuka I: Lack of (anti-) androgenic or estrogenic effects of three pyrethroids (esfenvalerate, fenvalerate, and permethrin) in the Hershberger and uterotrophic assays. Regul Toxicol Pharmacol. 2002 Apr;35(2 Pt 1):227-37.


In the present study, we evaluated the interaction of three pyrethroids (esfenvalerate, fenvalerate, and permethrin) with androgen receptor (AR)- and estrogen receptor (ER)-mediated mechanisms using in vivo short-term assays.
1(0,0,0,1) Details