| Name | glutathione S transferase |
|---|---|
| Synonyms | GST class alpha 2; Gst2; GST class alpha; GST class alpha member 2; GST gamma; GSTA 2; GSTA2; GSTA2 2… |
| Name | pyrethrins |
|---|---|
| CAS | pyrethrins |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 19225809 | Jagadeshwaran U, Vijayan VA: Biochemical characterization of deltamethrin resistance in a laboratory-selected strain of Aedes aegypti. Parasitol Res. 2009 Jun;104(6):1431-8. Epub 2009 Feb 19. Significant elevation in the activity of alpha- and beta-esterases, glucose-6-phosphate dehydrogenase (G6PD), CYTP450 (CYTP450), and glutathione-s-transferase (GST) were noticed in DR. |
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| 11603736 | Yang X, Zhu KY, Buschman LL, Margolies DC: Comparative susceptibility and possible detoxification mechanisms for selected miticides in banks grass mite and two-spotted spider mite (Acari: Tetranychidae). Exp Appl Acarol. 2001;25(4):293-9. The significant synergism with these pyrethroids of all three tested synergists (except for DEM with lambda-cyhalothrin against TSM) suggests that esterases, glutathione S-transferases, and cytochrome P450 monooxygenases all play important roles in their detoxification. |
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| 19274371 | Fonseca-Gonzalez I, Quinones ML, McAllister J, Brogdon WG: Mixed-function oxidases and esterases associated with cross-resistance between DDT and lambda-cyhalothrin in Anopheles darlingi Root 1926 populations from Colombia. Mem Inst Oswaldo Cruz. 2009 Feb;104(1):18-26. Enzyme levels related to insecticide resistance, including mixed function oxidases (MFO), non-specific esterases (NSE), glutathione S-transferases and modified acetylcholinesterase were evaluated in all populations and compared with a susceptible natural strain. |
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| 12866824 | Ganesh KN, Urmila J, Vijayan VA: Pyrethroid susceptibility & enzyme activity in two malaria vectors, Anopheles stephensi (Liston) &. Indian J Med Res. 2003 Jan;117:30-8. An attempt was also made to correlate the activities of certain detoxifying enzymes such as A- esterase, B-esterase, glutathione-S transferase (GST) and glucose-6-phosphate dehydrogenase (G6PD) with the tolerance levels of the two vectors. |
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| 11222940 | Kostaropoulos I, Papadopoulos AI, Metaxakis A, Boukouvala E, Papadopoulou-Mourkidou E: Glutathione S-transferase in the defence against pyrethroids in insects. Insect Biochem Mol Biol. 2001 Mar 15;31(4-5):313-9. |
2(0,0,0,2) | Details |
| 11297102 | Enayati AA, Vontas JG, Small GJ, McCarroll L, Hemingway J: Quantification of pyrethroid insecticides from treated bednets using a mosquito recombinant glutathione S-transferase. Med Vet Entomol. 2001 Mar;15(1):58-63. |
2(0,0,0,2) | Details |
| 18179425 | Muller P, Chouaibou M, Pignatelli P, Etang J, Walker ED, Donnelly MJ, Simard F, Ranson H: Pyrethroid tolerance is associated with elevated expression of antioxidants and agricultural practice in Anopheles arabiensis sampled from an area of cotton fields in Northern Cameroon. Mol Ecol. 2008 Feb;17(4):1145-55. Epub 2007 Dec 20. Several genes with antioxidant roles, including superoxide dismutases, a glutathione S-transferase and a thioredoxin-dependent peroxidase, and a cytochrome P450 showed elevated expression in mosquito families collected during the insecticide-spraying programme. |
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| 17710279 | Dzul FA, Patricia Penilla R, Rodriguez AD: [Susceptibility and insecticide resistance mechanisms in Anopheles albimanus from the southern Yucatan Peninsula, Mexico]. Salud Publica Mex. 2007 Jul-Aug;49(4):302-11. Biochemical assays showed high levels of glutathione S-transferase (GST), cytochrome P450 and esterases (with pNPA substrate) in all villages. |
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| 15780344 | Enayati AA, Lengeler C, Erlanger T, Hemingway J: Field evaluation of a recombinant glutathione S-transferase-based pyrethroid quantification assay. Trans R Soc Trop Med Hyg. 2005 May;99(5):369-78. |
2(0,0,0,2) | Details |
| 12206409 | Gowlan BT, Moffat CF, Stagg RM, Houlihan DF, Davies IM: Cypermethrin induces glutathione S-transferase activity in the shore crab, Carcinus maenas. Mar Environ Res. 2002 Aug;54(2):169-77. |
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| 15556070 | Papadopoulos AI, Polemitou I, Laifi P, Yiangou A, Tananaki C: Glutathione S-transferase in the insect Apis mellifera macedonica kinetic characteristics and effect of stress on the expression of GST isoenzymes in the adult worker bee. Comp Biochem Physiol C Toxicol Pharmacol. 2004 Oct;139(1-3):93-7. |
2(0,0,0,2) | Details |
| 19038063 | Munhenga G, Masendu HT, Brooke BD, Hunt RH, Koekemoer LK: Pyrethroid resistance in the major malaria vector Anopheles arabiensis from Gwave, a malaria-endemic area in Zimbabwe. Malar J. 2008 Nov 28;7:247. Biochemical assays were used to determine the relative levels of detoxifying enzyme systems including non-specific esterases, monooxygenases and glutathione-S-transferases as well as to detect the presence of an altered acetylcholine esterase (AChE). |
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| 19687627 | Raina R, Verma PK, Pankaj NK, Prawez S: Induction of oxidative stress and lipid peroxidation in rats chronically exposed to cypermethrin through dermal application. J Vet Sci. 2009 Sep;10(3):257-9. However, the activity of glutathione S-transferase increased significantly (p < 0.05) in all groups after 60 days of dermal exposure. |
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| 11439246 | Jirajaroenrat K, Pongjaroenkit S, Krittanai C, Prapanthadara L, Ketterman AJ: Heterologous expression and characterization of alternatively spliced glutathione S-transferases from a single Anopheles gene. Insect Biochem Mol Biol. 2001 Jul 26;31(9):867-75. |
2(0,0,0,2) | Details |
| 15157234 | da Silva Vaz Jnr I, Imamura S, Ohashi K, Onuma M: Cloning, expression and partial characterization of a Haemaphysalis longicornis and a Rhipicephalus appendiculatus glutathione S-transferase. Insect Mol Biol. 2004 Jun;13(3):329-35. |
2(0,0,0,2) | Details |
| 11415437 | Vontas JG, Small GJ, Hemingway J: Glutathione S-transferases as antioxidant defence agents confer pyrethroid resistance in Nilaparvata lugens. Biochem J. 2001 Jul 1;357(Pt 1):65-72. |
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| 15186033 | el-Demerdash FM, Yousef MI, Kedwany FS, Baghdadi HH: Role of and in ameliorating the fenvalerate-induced changes in oxidative stress, hemato-biochemical parameters, and semen quality of male rats. J Environ Sci Health B. 2004 May;39(3):443-59. The activities of glutathione S-transferase (liver), alkaline phosphatase (plasma and liver), aspartate aminotransferase (plasma, liver, and testes) and alanine aminotransferase (plasma and liver) were significantly (P < 0.05) increased due to fenvalerate administration. |
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| 19610439 | Ramoutar D, Cowles RS, Alm SR: Pyrethroid resistance mediated by enzyme detoxification in Listronotus maculicollis (Coleoptera: Curculionidae) from Connecticut. J Econ Entomol. 2009 Jun;102(3):1203-8. In this study, topical application bioassays with bifenthrin and bifenthrin combined with synergists affecting three detoxification systems were conducted on four field-collected adult populations of L. maculicollis from Connecticut to determined whether cytochrome P450 monooxgenases (P450s), glutathione S-transferases (GSTs), and/or carboxyl-esterases (COEs) mediated metabolic detoxification. |
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| 18392087 | Enayati AA, Motevalli Haghi F: Biochemistry of pyrethroid resistance in German cockroach (Dictyoptera, Blatellidae) from hospitals of Sari, Iran. Iran Biomed J. 2007 Oct;11(4):251-8. Biochemical assays of esterases, monooxigenases and glutathione S-transferase (GST) levels were undertaken on German cockroaches from Imam and Bouali Cina Hospitals and the results were compared to a susceptible laboratory strain. |
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| 19125173 | Pasay C, Arlian L, Morgan M, Gunning R, Rossiter L, Holt D, Walton S, Beckham S, McCarthy J: The effect of insecticide synergists on the response of scabies mites to pyrethroid acaricides. PLoS Negl Trop Dis. 2009;3(1):e354. Epub 2009 Jan 6. Then, to investigate the relative role of specific metabolic pathways inhibited by these synergists, enzyme assays were developed to measure esterase, glutathione S-transferase (GST) and cytochrome P450 monooxygenase (cytochrome P450) activity in mite extracts. |
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| 16105448 | Li HY, Shi N, Chen D, Dai ZH, Lu WH, Wang B, Li YR: [Oxidative stress of deltamethrin on rat nervous system] . Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2005 Apr;23(2):97-101. The content of malondialdehyde (MDA) and the activity of total-superoxide dismutase (T-SOD, including Mn-SOD and CuZn-SOD), catalase (CAT), glutathione-S-transferase (GST), peroxidase (GSH-Px) and glutathione reductase (GR) in cerebral cortex and hippocampus tissue were determined. |
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| 17633433 | Etang J, Manga L, Toto JC, Guillet P, Fondjo E, Chandre F: Spectrum of metabolic-based resistance to DDT and pyrethroids in Anopheles gambiae s.l. populations from Cameroon. J Vector Ecol. 2007 Jun;32(1):123-33. This study reports on the metabolic activity of non-specific esterases (NSEs), mixed function oxidases (MFOs), and glutathione S-transferases (GSTs), three enzyme systems commonly involved in insecticide resistance. |
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| 18399473 | Mesbah HA, Saad AS, Mourad AK, Taman FA, Mohamed IB: Joint action of with four insecticides on the cotton leaf-worm larvae, Spodoptera littoralis Boisd. (Lep. : Noctuidae) in Egypt. Commun Agric Appl Biol Sci. 2007;72(3):445-57. role as a synergist might be attributed to its ability to inhibit certain active oxidases, which may be responsible for in vivo detoxification of the intact insecticides when applied to insect larvae, through glutathione-S-transferase. |
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| 19817123 | Omer SA, Konate G, Traore O, Traore O, Menozzi P: Biochemical characterization of the cotton bollworm Helicoverpa armigera resistance to pyrethroids in Burkina Faso. Pak J Biol Sci. 2009 Jul 1;12(13):964-9. Activities of two types of enzymes i.e., oxidases and Glutathione-S-Transferases (GST) were significantly higher in field strains, whereas esterase activities were lower compared to that of standard strain. |
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| 12622206 | Ganesh KN, Vijayan VA, Urmila J, Gopalan N, Prakash S: Role of esterases and monooxygenase in the deltamethrin resistance in Anopheles stephensi Giles (1908), at Mysore. Indian J Exp Biol. 2002 May;40(5):583-8. The reason for this kind of resistance was analyzed on the basis of differential activity of A-esterase, B-esterase, glutathione s-transferase (GST) and glucose 6-phosphate dehydrogenase (G6PD). |
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| 15849966 | Rodriguez MM, Bisset JA, Diaz C, Soca LA: [Cross resistance to pyrethroids in Aedes aegypti from Cuba induced by the selection with organophosphate malathion]. Rev Cubana Med Trop. 2003 May-Aug;55(2):105-11. Nevertheless, there was an increase in the frequency of the glutathione-s-transferase mechanism from 0.049 in Santiago de Cuba to 0.42 in SAN-F5, which may be associated with the resistance to pyrethroids. |
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| 14651656 | Hargreaves K, Hunt RH, Brooke BD, Mthembu J, Weeto MM, Awolola TS, Coetzee M: Anopheles arabiensis and An. quadriannulatus resistance to DDT in South Africa. Med Vet Entomol. 2003 Dec;17(4):417-22. Biochemical analyses of samples from each of the families revealed comparatively high levels of glutathione-S-transferases and non-specific esterases in some families, but without significant correlation to bioassay results. |
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| 15154513 | Ahmad M, Hollingworth RM: Synergism of insecticides provides evidence of metabolic mechanisms of resistance in the obliquebanded leafroller Choristoneura rosaceana (Lepidoptera: Tortricidae). Pest Manag Sci. 2004 May;60(5):465-73. These studies indicate that enhanced detoxification, often mediated by cytochrome P-450 monooxygenases, but with probable esterase and glutathione S-transferase contributions in some cases, is the major mechanism imparting resistance to different insecticides in C. rosaceana. |
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| 16506569 | Rodriguez MM, Bisset JA, De Armas Y, Ramos F: Pyrethroid insecticide-resistant strain of Aedes aegypti from Cuba induced by deltamethrin selection. J Am Mosq Control Assoc. 2005 Dec;21(4):437-45. Synergism tests implicated detoxifying esterase or glutathione S-transferase (GST) and monooxygenase in pyrethroid resistance. |
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| 17370803 | Booth LH, Wratten SD, Kehrli P: Effects of reduced rates of two insecticides on enzyme activity and mortality of an aphid and its lacewing predator. J Econ Entomol. 2007 Feb;100(1):11-9. Cholinesterase (ChE) and glutathione S-transferase (GST) activities in survivors provided a measure of sublethal effects and general fitness. |
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| 19556575 | Martins AJ, Lins RM, Linss JG, Peixoto AA, Valle D: Voltage-gated sodium channel polymorphism and metabolic resistance in pyrethroid-resistant Aedes aegypti from Brazil. Am J Trop Med Hyg. 2009 Jul;81(1):108-15. Quantification of enzymes related to metabolic resistance in two distinct populations, located in the Northeast and Southeast regions, revealed increases in Glutathione-S-transferase (GST) and Esterase levels. |
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| 12680930 | Brengues C, Hawkes NJ, Chandre F, McCarroll L, Duchon S, Guillet P, Manguin S, Morgan JC, Hemingway J: Pyrethroid and DDT cross-resistance in Aedes aegypti is correlated with novel mutations in the voltage-gated sodium channel gene. Med Vet Entomol. 2003 Mar;17(1):87-94. Glutathione S-transferase activity was elevated in the Guyane strain. |
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| 15499499 | Greulich K, Pflugmacher S: Uptake and effects on detoxication enzymes of cypermethrin in embryos and tadpoles of amphibians. Arch Environ Contam Toxicol. 2004 Nov;47(4):489-95. In tadpoles of B. variegata and R. arvalis, the activity of microsomal and cytosolic glutathione S-transferase (mGST and sGST, respectively) were measured after treatment with cypermethrin. |
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| 17385498 | Rattanapan A, Visetson S, Ngernsiri L, Milne J: Efficiency of Thai derris extract and cypermethrin: toxicity and detoxification enzyme mechanism in the tropical armyworm, Spodoptera litura F. Commun Agric Appl Biol Sci. 2006;71(2 Pt B):329-37. While the crude extract tendency induced the glutathione-S-transferase enzyme activities more than cypermethrin ca. 0.04 fold. |
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| 16499895 | Rehman H, Ali M, Atif F, Kaur M, Bhatia K, Raisuddin S: The modulatory effect of deltamethrin on antioxidants in mice. Clin Chim Acta. 2006 Jul 15;369(1):61-5. Epub 2006 Feb 24. Along with the induction of LPO, activities of vital antioxidant enzymes such as peroxidase (GPx), glutathione S-transferase (GST) and catalase (CAT) were also suppressed in both the tissues. |
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| 17137748 | El-Demerdash FM: Lambda-cyhalothrin-induced changes in oxidative stress biomarkers in rabbit erythrocytes and alleviation effect of some antioxidants. Toxicol In Vitro. 2007 Apr;21(3):392-7. Epub 2006 Oct 1. However, a significant decrease in the content of sulfhydryl groups (SH-groups), and the activities of acetylcholinesterase (AChE), superoxide dismutase (SOD), catalase (CAT) and glutathione S-transferase (GST) were observed. |
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| 16001157 | Atif F, Parvez S, Pandey S, Ali M, Kaur M, Rehman H, Khan HA, Raisuddin S: Modulatory effect of cadmium exposure on deltamethrin-induced oxidative stress in Channa punctata Bloch. Arch Environ Contam Toxicol. 2005 Oct;49(3):371-7. Epub 2005 Jul 6. Activities of peroxidase, glutathione reductase, and glutathione-S-transferase were also studied in liver, kidney, and gills. |
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| 12716053 | el-Demerdash FM, Yousef MI, Al-Salhen KS: Protective effects of isoflavone on some biochemical parameters affected by cypermethrin in male rabbits. J Environ Sci Health B. 2003 May;38(3):365-78. The activities of glutathione S-transferase (GST) (liver, brain and testes), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) (liver and testes), and alkaline phosphatase (AlP) (liver) were significantly (P < 0.05) decreased due to cypermethrin administration. |
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| 17261191 | Muller P, Donnelly MJ, Ranson H: Transcription profiling of a recently colonised pyrethroid resistant Anopheles gambiae strain from Ghana. BMC Genomics. 2007 Jan 29;8:36. Although three enzyme families (cytochrome P450s, glutathione S-transferases and carboxylesterases) have been widely associated with insecticide detoxification the role of individual enzymes is largely unknown. |
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| 12232873 | Bouvier JC, Boivin T, Beslay D, Sauphanor B: Age-dependent response to insecticides and enzymatic variation in susceptible and resistant codling moth larvae. Arch Insect Biochem Physiol. 2002 Oct;51(2):55-66. The age variation of the activities of cytochrome P450-dependent monooxygenase (MFO), glutathione S-transferases (GST), and esterases in S and both resistant strains were simultaneously investigated. |
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| 15262281 | Yang Y, Wu Y, Chen S, Devine GJ, Denholm I, Jewess P, Moores GD: The involvement of microsomal oxidases in pyrethroid resistance in Helicoverpa armigera from Asia. Insect Biochem Mol Biol. 2004 Aug;34(8):763-73. In the resistant strains, minor increases in glutathione S-transferase activity (to the substrates CDNB and DCNB), and esterase activity (to the substrate alpha-naphthyl further suggested that, of the putative metabolic mechanisms, oxidases are the most important. |
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| 18508027 | Daaboub J, Ben Cheikh R, Lamari A, Ben Jha I, Feriani M, Boubaker C, Ben Cheikh H: Resistance to pyrethroid insecticides in Culex pipiens pipiens (Diptera: Culicidae) from Tunisia. Acta Trop. 2008 Jul;107(1):30-6. Epub 2008 Apr 22. The use of synergists showed that the cytochrome P450-dependent monooxygenases had a major contribution to the permethrin and deltamethrin resistance and that the esterases (and/or glutathione-S-transferases) had only a minor contribution. |
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| 16937654 | Johnson RM, Wen Z, Schuler MA, Berenbaum MR: Mediation of pyrethroid insecticide toxicity to honey bees (Hymenoptera: Apidae) by cytochrome P450 monooxygenases. J Econ Entomol. 2006 Aug;99(4):1046-50. Metabolic insecticide resistance in other insects is mediated by three major groups of detoxifying enzymes: the cytochrome P450 monooxygenases (P450s), the carboxylesterases (COEs), and the glutathione S-transferases (GSTs). |
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| 12831135 | Chareonviriyaphap T, Rongnoparut P, Chantarumporn P, Bangs MJ: Biochemical detection of pyrethroid resistance mechanisms in Anopheles minimus in Thailand. J Vector Ecol. 2003 Jun;28(1):108-16. Expression of levels of non-specific esterases, monooxygenases, and glutathione S-transferases (GSTs) were measured. |
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| 16978760 | Yousef MI, Awad TI, Mohamed EH: Deltamethrin-induced oxidative damage and biochemical alterations in rat and its attenuation by Toxicology. 2006 Oct 29;227(3):240-7. Epub 2006 Aug 14. The activities of glutathione S-transferase (GST) and superoxide dismutase (SOD) were significantly decreased due to deltamethrin administration. |
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| 14630057 | Grajeda-Cota P, Ramirez-Mares MV, Gonzalez de Mejia E: protects against in vitro cytotoxicity of cypermethrin in rat hepatocytes. Toxicol In Vitro. 2004 Feb;18(1):13-9. and the activities of glutathione-S-transferase (GST) and gamma glutamyl transpeptidase (gamma-GT) were also measured. |
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| 11332829 | Yang X, Margolies DC, Zhu KY, Buschman LL: Host plant-induced changes in detoxification enzymes and susceptibility to pesticides in the twospotted spider mite (Acari: Tetranychidae). J Econ Entomol. 2001 Apr;94(2):381-7. Susceptibility was inversely related to activities of both general esterase and glutathione S-transferase (GST) in mites on cucumber; general esterase and GST activities were 60 and 25% lower, respectively, than activities of twospotted spider mite on lima bean after 7 d of feeding. |
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