| Name | carboxylesterase 1 |
|---|---|
| Synonyms | ACAT; Cholesteryl ester hydrolase; CES1; SES 1; SES1; ANAE; Acid esterase; Acyl coenzyme A cholesterol acyltransferase… |
| Name | pyrethrins |
|---|---|
| CAS | pyrethrins |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16167828 | Huang H, Fleming CD, Nishi K, Redinbo MR, Hammock BD: Stereoselective hydrolysis of pyrethroid-like fluorescent substrates by human and other mammalian liver carboxylesterases. Chem Res Toxicol. 2005 Sep;18(9):1371-7. |
2(0,0,0,2) | Details |
| 17442360 | Crow JA, Borazjani A, Potter PM, Ross MK: Hydrolysis of pyrethroids by human and rat tissues: examination of intestinal, liver and serum carboxylesterases. Toxicol Appl Pharmacol. 2007 May 15;221(1):1-12. Epub 2007 Mar 12. Moreover, a 6-fold interindividual variation in carboxylesterase 1 protein expression in human hepatic cytosols was observed. |
1(0,0,0,1) | Details |
| 16011852 | Wheelock CE, Eder KJ, Werner I, Huang H, Jones PD, Brammell BF, Elskus AA, Hammock BD: Individual variability in esterase activity and CYP1A levels in Chinook salmon (Oncorhynchus tshawytscha) exposed to esfenvalerate and chlorpyrifos. Aquat Toxicol. 2005 Aug 30;74(2):172-92. In contrast, liver carboxylesterase activity was significantly inhibited at both the low and high chlorpyrifos dose exposure (56% and 79% inhibition, respectively), while esfenvalerate exposure still had little effect. |
1(0,0,0,1) | Details |
| 16169030 | Anand SS, Bruckner JV, Haines WT, Muralidhara S, Fisher JW, Padilla S: Characterization of deltamethrin metabolism by rat plasma and liver microsomes. Toxicol Appl Pharmacol. 2006 Apr 15;212(2):156-66. Epub 2005 Sep 16. The rate constants for liver carboxylesterases were Vmax=1981.8+/-132.3 nmol/h/g liver and Km=172.5+/-22.5 microM. |
1(0,0,0,1) | Details |
| 16359636 | Nishi K, Huang H, Kamita SG, Kim IH, Morisseau C, Hammock BD: Characterization of pyrethroid hydrolysis by the human liver carboxylesterases hCE-1 and hCE-2. Arch Biochem Biophys. 2006 Jan 1;445(1):115-23. |
1(0,0,0,1) | Details |
| 15777092 | Huang H, Stok JE, Stoutamire DW, Gee SJ, Hammock BD: Development of optically pure pyrethroid-like fluorescent substrates for carboxylesterases. Chem Res Toxicol. 2005 Mar;18(3):516-27. In addition, stereointeraction between carboxylesterases and chiral fluorescent substrates indicated that (i) stereospecificity of recombinant mouse liver carboxylesterases (NCBI accession nos. |
1(0,0,0,1) | Details |
| 16855054 | Godin SJ, Scollon EJ, Hughes MF, Potter PM, DeVito MJ, Ross MK: Species differences in the in vitro metabolism of deltamethrin and esfenvalerate: differential oxidative and hydrolytic metabolism by humans and rats. Drug Metab Dispos. 2006 Oct;34(10):1764-71. Epub 2006 Jul 19. Results of CE metabolism revealed that human carboxylesterase 1 (hCE-1) was markedly more active toward deltamethrin than the class 1 rat CEs hydrolase A and B and the class 2 human CE (hCE-2); however, hydrolase A metabolized esfenvalerate 2-fold faster than hCE-1, whereas hydrolase B and hCE-1 hydrolyzed esfenvalerate at equal rates. |
1(0,0,0,1) | Details |