| Name | CYP2B |
|---|---|
| Synonyms | CYP2B; CYP2B7; CYP2B7P; CYP2B protein; CYP2B7P1; CYP2B7P1 protein; CYP2B7P1 proteins |
| Name | pyrethrins |
|---|---|
| CAS | pyrethrins |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17188729 | Price RJ, Walters DG, Finch JM, Gabriel KL, Capen CC, Osimitz TG, Lake BG: A mode of action for induction of liver tumors by Pyrethrins in the rat. Toxicol Appl Pharmacol. 2007 Jan 15;218(2):186-95. Epub 2006 Nov 11. The mode of action for Pyrethrins-induced rat liver tumor formation appears to be similar to that of NaPB and some other non-genotoxic CYP2B inducers of hepatic xenobiotic metabolism. |
43(0,1,3,3) | Details |
| 18022748 | Price RJ, Giddings AM, Scott MP, Walters DG, Capen CC, Osimitz TG, Lake BG: Effect of Pyrethrins on cytochrome P450 forms in cultured rat and human hepatocytes. Toxicology. 2008 Jan 14;243(1-2):84-95. Epub 2007 Oct 7. Pyrethrins induce CYP2B and CYP3A forms in cultured rat hepatocytes and can induce CYP3A and CYP2B forms in human hepatocytes. |
6(0,0,1,1) | Details |
| 19176367 | Yamada T, Uwagawa S, Okuno Y, Cohen SM, Kaneko H: Case study: an evaluation of the human relevance of the synthetic pyrethroid metofluthrin-induced liver tumors in rats based on mode of action. Toxicol Sci. 2009 Mar;108(1):59-68. Epub 2009 Jan 27. Metofluthrin induced CYP2B (increased smooth endoplasmic reticulum), resulted in increased liver weights which were associated with centrilobular hepatocyte hypertrophy, and induction of increased hepatocellular DNA replications. |
2(0,0,0,2) | Details |
| 19176366 | Deguchi Y, Yamada T, Hirose Y, Nagahori H, Kushida M, Sumida K, Sukata T, Tomigahara Y, Nishioka K, Uwagawa S, Kawamura S, Okuno Y: Mode of action analysis for the synthetic pyrethroid metofluthrin-induced rat liver tumors: evidence for hepatic CYP2B induction and hepatocyte proliferation. Toxicol Sci. 2009 Mar;108(1):69-80. Epub 2009 Jan 27. |
2(0,0,0,2) | Details |