| Name | cytochrome P450 monooxygenase |
|---|---|
| Synonyms | CYP M; CYP20A1; CYP20A1 protein; Cytochrome P450 family 20 subfamily A polypeptide 1; Cytochrome P450 monooxygenase; CYP20A1 proteins; Cytochrome P450 family 20 subfamily A polypeptide 1s; Cytochrome P450 monooxygenases |
| Name | emamectin |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16269733 | Molnar I, Hill DS, Zirkle R, Hammer PE, Gross F, Buckel TG, Jungmann V, Pachlatko JP, Ligon JM: Biocatalytic conversion of avermectin to 4"-oxo-avermectin: heterologous expression of the ema1 cytochrome P450 monooxygenase. Appl Environ Microbiol. 2005 Nov;71(11):6977-85. The cytochrome P450 monooxygenase Ema1 from Streptomyces tubercidicus R-922 and its homologs from closely related Streptomyces strains are able to catalyze the regioselective oxidation of avermectin into 4"-oxo-avermectin, a key intermediate in the manufacture of the agriculturally important insecticide emamectin (V. |
32(0,1,1,2) | Details |
| 16269732 | Jungmann V, Molnar I, Hammer PE, Hill DS, Zirkle R, Buckel TG, Buckel D, Ligon JM, Pachlatko JP: Biocatalytic conversion of avermectin to 4"-oxo-avermectin: characterization of biocatalytically active bacterial strains and of cytochrome p450 monooxygenase enzymes and their genes. Appl Environ Microbiol. 2005 Nov;71(11):6968-76. 4"-Oxo-avermectin is a key intermediate in the manufacture of the agriculturally important insecticide emamectin from the natural product avermectin. |
2(0,0,0,2) | Details |
| 17483257 | Trefzer A, Jungmann V, Molnar I, Botejue A, Buckel D, Frey G, Hill DS, Jorg M, Ligon JM, Mason D, Moore D, Pachlatko JP, Richardson TH, Spangenberg P, Wall MA, Zirkle R, Stege JT: Biocatalytic conversion of avermectin to 4''-oxo-avermectin: improvement of cytochrome p450 monooxygenase specificity by directed evolution. Appl Environ Microbiol. 2007 Jul;73(13):4317-25. Epub 2007 May 4. Discovery of the CYP107Z subfamily of cytochrome P450 oxidases (CYPs) led to an alternative biocatalytic synthesis of 4''-oxo-avermectin, a key intermediate for the commercial production of the semisynthetic insecticide emamectin. |
1(0,0,0,1) | Details |