Protein Information

Name glutathione S transferase
Synonyms GST class alpha 2; Gst2; GST class alpha; GST class alpha member 2; GST gamma; GSTA 2; GSTA2; GSTA2 2…

Compound Information

Name nitrostyrene
CAS 4-(2-nitro-1-propenyl)phenyl thiocyanate

Reference List

PubMed Abstract RScore(About this table)
1683476 Trenga CA, Kunkel DD, Eaton DL, Costa LG: Effect of styrene oxide on rat brain glutathione. . Neurotoxicology. 1991 Summer;12(2):165-78.

Glutathione S-transferase activity in different brain regions, measured using p-nitrostyrene oxide as a substrate, correlated quantitatively with GSH depletion by styrene oxide.
31(0,1,1,1) Details
6812568 Wackett LP, Gibson DT: Metabolism of xenobiotic compounds by enzymes in cell extracts of the fungus Cunninghamella elegans. Biochem J. 1982 Jul 1;205(1):117-22.

Cell extracts of the filamentous fungus Cunninghamella elegans contain epoxide hydrolase (EC 3.3.2.3), glutathione S-transferase (EC 2.5.1.18) and UDP-glucuronosyltransferase (EC 2.4.1.17) activities.
Epoxide hydrolase activity was determined with p-nitrostyrene oxide as substrate and was shown to be associated with the 100 000 g pellet obtained from disrupted mycelia.
3(0,0,0,3) Details
3116723 Monroe DH, Eaton DL: Comparative effects of butylated hydroxyanisole on hepatic in vivo DNA binding and in vitro biotransformation of aflatoxin B1 in the rat and mouse. Toxicol Appl Pharmacol. 1987 Sep 30;90(3):401-9.

Control mice had 52 times greater glutathione S-transferase (GST) activity toward the AFB-epoxide, but only 2.6 times greater GST activity toward 1-chloro-2,4-dinitrobenzene (CDNB), compared to that of control rats.
Epoxide hydrolase activity toward p-nitrostyrene oxide in mice was only 52% of the activity in rats.
1(0,0,0,1) Details