Protein Information

Name cholinesterase
Synonyms Acylcholine acylhydrolase; BCHE; BCHE protein; Butyrylcholine esterase; Butyrylcholinesterase; CHE1; Choline esterase II; Cholinesterase…

Compound Information

Name quinalphos
CAS

Reference List

PubMed Abstract RScore(About this table)
6658822 Srivastava AK, Paul BS, Malik JK: Effect of repeated oral administration of quinalphos on blood esterases in Bubalus bubalis. Toxicol Lett. 1983 Oct-Nov;19(1-2):165-9.

Quinalphos markedly inactivated serum carboxylesterase (69-90%) and plasma cholinesterase activity (75-88%).
81(1,1,1,1) Details
8258630 Jokanovic M: Studies on the delayed neuropathic and anticholinesterase potential of quinalphos (diethyl 2-quinoxalyl phosphorothionate) in hens. J Appl Toxicol. 1993 Sep-Oct;13(5):337-9.

Incidence of numerous human poisonings by quinalphos (Ekalux, Bayrusil) in agricultural areas near Belgrade initiated this study on the ability of the compound to inhibit hen brain neuropathy target esterase, acetylcholinesterase and plasma butyrylcholinesterase in vivo.
68(0,2,3,3) Details
8351793 Raizada RB, Srivastava MK, Singh RP, Kaushal RA, Gupta KP, Dikshith TS: Acute and subchronic oral toxicity of technical quinalphos in rats. Vet Hum Toxicol. 1993 Jun;35(3):223-5.

Male rats were more susceptible to quinalphos than female rats in the subchronic toxicity studies based on mortality, enzyme profiles and cholinesterase inhibition.
31(0,1,1,1) Details
1375016 Vasilic Z, Drevenkar V, Rumenjak V, Stengl B, Frobe Z: Urinary excretion of diethylphosphorus metabolites in persons poisoned by quinalphos or chlorpyrifos. Arch Environ Contam Toxicol. 1992 May;22(4):351-7.

The urinary excretion rates of diethyl phosphate and diethyl phosphorothioate and changes in blood cholinesterase activities were studied in fifteen persons self-poisoned either by the organophosphorus pesticide quinalphos (twelve persons) or by chlorpyrifos (three persons).
8(0,0,1,3) Details
1675101 Kusic R, Jovanovic D, Randjelovic S, Joksovic D, Todorovic V, Boskovic B, Jokanovic M, Vojvodic V: HI-6 in man: efficacy of the oxime in poisoning by organophosphorus insecticides. Hum Exp Toxicol. 1991 Mar;10(2):113-8.

Although both HI-6 and pralidoxime chloride reactivated the red blood cell cholinesterase in quinalphos-poisoned subjects, the return of enzyme activities was more rapid following the use of HI-6.
6(0,0,1,1) Details
3675088 Bokonjic D, Jovanovic D, Jokanovic M, Maksimovic M: Protective effects of oximes HI-6 and PAM-2 applied by osmotic minipumps in quinalphos-poisoned rats. Arch Int Pharmacodyn Ther. 1987 Aug;288(2):309-18.

PAM-2 concentrations, continuously maintained in plasma, were distinctly better in protecting and reactivating peripheral cholinesterase activity than corresponding HI-6 concentrations in the case of quinalphos poisoning.
6(0,0,1,1) Details
8031730 Durakovic Z: Combined hemoperfusion and hemodialysis treatment of poisoning with cholinesterase inhibitors. Korean J Intern Med. 1993 Jul;8(2):99-102.

2(0,0,0,2) Details
6853013 Drevenkar V, Stengl B, Tkalcevic B, Vasilic Z: Occupational exposure control by simultaneous determination of N-methylcarbamates and organophosphorus pesticide residues in human urine. Int J Environ Anal Chem. 1983;14(3):215-30.


The level of extracted N-methylcarbamates and the concentration of degradation products of organophosphorus pesticides detected in the urine of the same persons were correlated with the blood and plasma cholinesterase activities.
2(0,0,0,2) Details
10713464 Das BK, Mukherjee SC: Chronic toxic effects of quinalphos on some biochemical parameters in Labeo rohita (Ham.). Toxicol Lett. 2000 Apr 3;114(1-3):11-8.

The brain acetyl cholinesterase activity was decreased most (-75.43%) in 1.12 mg/l concentration over a period of 45 days.
1(0,0,0,1) Details