| Name | tumor necrosis factor alpha |
|---|---|
| Synonyms | Cachectin; DIF; TNF; TNF alpha; TNF a; TNFA; TNFSF 2; TNFSF2… |
| Name | simazine |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 12791541 | Kim KR, Son EW, Hee-Um S, Kim BO, Rhee DK, Pyo S: Immune alterations in mice exposed to the herbicide simazine. . J Toxicol Environ Health A. 2003 Jun 27;66(12):1159-73. Exposure to simazine also decreased cytokine production by macrophages, such as interleukin-1 (IL-1), IL-6, and tumor necrosis factor-alpha (TNF-alpha). |
31(0,1,1,1) | Details |
| 12206818 | Kim KR, Son EW, Rhee DK, Pyo S: The immunomodulatory effects of the herbicide simazine on murine macrophage functions in vitro. Toxicol In Vitro. 2002 Oct;16(5):517-23. In addition, the production of (NO) and tumor necrosis factor-alpha (TNF-alpha) which have been known to be major effector molecules in macrophage-mediated cytotoxicity was decreased by simazine pretreatment in a dose-dependent manner. |
31(0,1,1,1) | Details |
| 10883730 | Hooghe RJ, Devos S, Hooghe-Peters EL: Effects of selected herbicides on cytokine production in vitro. Life Sci. 2000 May 19;66(26):2519-25. After in vitro exposure of human peripheral blood mononuclear cells from normal donors, the production of all 3 cytokines tested--interferon-gamma (a type 1 cytokine), interleukin-5 (a type 2 cytokine) and tumor necrosis factor-alpha (an inflammatory cytokine)--was impaired by up to 70, 50 and 70% respectively in a concentration-dependent manner in cultures exposed to atrazine (0.03-3 microM in 1% dimethylsulfoxide, DMSO). Other pesticides also dissolved in DMSO--mecoprop, simazine or MCPA (each up to 1 microM)--or dissolved in -buffered saline--diuron (up to 1 microM), isoproturon (up to 3 microM), metoxuron (up to 8 microM) or metamitron (up to 80 microM)--showed no concentration-related effects on cytokine production. |
1(0,0,0,1) | Details |
| 15256756 | Hong CC, Shimomura-Shimizu M, Muroi M, Tanamoto K: Effect of endocrine disrupting chemicals on lipopolysaccharide-induced tumor necrosis factor-alpha and production by mouse macrophages. Biol Pharm Bull. 2004 Jul;27(7):1136-9. To assess the effect of EDCs on the development of infectious disease, we investigated the effect of eighteen possible EDCs on mouse macrophage production of tumor necrosis factor-alpha (TNF-alpha) and (NO) in response to bacterial endotoxin in vitro and ex vivo. Of chemicals we examined, simazine, nitrofen, and benzyl butyl inhibited lipopolysaccharide (LPS)-induced TNF-alpha production by mouse macrophage cell line RAW 264 in vitro. |
1(0,0,0,1) | Details |