Protein Information

Name homeobox
Synonyms HPX 6; HPX6; LBX 1; LBX1; LBX1H; Lady bird like homeobox; Ladybird homeobox protein homolog 1; Transcription factor LBX1…

Compound Information

Name gibberellins
CAS gibberellins

Reference List

PubMed Abstract RScore(About this table)
16861569 Sakamoto T, Sakakibara H, Kojima M, Yamamoto Y, Nagasaki H, Inukai Y, Sato Y, Matsuoka M: Ectopic expression of KNOTTED1-like homeobox protein induces expression of cytokinin biosynthesis genes in rice. Plant Physiol. 2006 Sep;142(1):54-62. Epub 2006 Jul 21.

Some phytohormones such as gibberellins (GAs) and cytokinins (CKs) are potential targets of the KNOTTED1-like homeobox (KNOX) protein.
81(1,1,1,1) Details
12746517 Rosin FM, Hart JK, Horner HT, Davies PJ, Hannapel DJ: Overexpression of a knotted-like homeobox gene of potato alters vegetative development by decreasing gibberellin accumulation. Plant Physiol. 2003 May;132(1):106-17.

3(0,0,0,3) Details
12372247 Hay A, Kaur H, Phillips A, Hedden P, Hake S, Tsiantis M: The gibberellin pathway mediates KNOTTED1-type homeobox function in plants with different body plans. Curr Biol. 2002 Sep 17;12(18):1557-65.

2(0,0,0,2) Details
16215272 Rueda EC, Dezar CA, Gonzalez DH, Chan RL: Hahb-10, a sunflower homeobox-leucine zipper gene, is regulated by light quality and quantity, and promotes early flowering when expressed in Arabidopsis. Plant Cell Physiol. 2005 Dec;46(12):1954-63. Epub 2005 Oct 8.

Induction of Hahb-10 expression was observed when seedlings were subjected to treatment with gibberellins.
2(0,0,0,2) Details
9750350 Tanaka-Ueguchi M, Itoh H, Oyama N, Koshioka M, Matsuoka M: Over-expression of a tobacco homeobox gene, NTH15, decreases the expression of a gibberellin biosynthetic gene encoding GA 20-oxidase. Plant J. 1998 Aug;15(3):391-400.

2(0,0,0,2) Details
15057937 Hay A, Craft J, Tsiantis M: Plant hormones and homeoboxes: bridging the gap? . Bioessays. 2004 Apr;26(4):395-404.

2(0,0,0,2) Details
18952778 Lo SF, Yang SY, Chen KT, Hsing YI, Zeevaart JA, Chen LJ, Yu SM: A novel class of gibberellin 2-oxidases control semidwarfism, tillering, and root development in rice. Plant Cell. 2008 Oct;20(10):2603-18. Epub 2008 Oct 24.

Gibberellin 2-oxidases (GA2oxs) regulate plant growth by inactivating endogenous bioactive gibberellins (GAs).
GA negatively regulated expression of two transcription factors, O. sativa homeobox 1 and TEOSINTE BRANCHED1, which control meristem initiation and axillary bud outgrowth, respectively, and that in turn inhibited tillering.
1(0,0,0,1) Details
18184732 Depuydt S, Dolezal K, Van Lijsebettens M, Moritz T, Holsters M, Vereecke D: Modulation of the hormone setting by Rhodococcus fascians results in ectopic KNOX activation in Arabidopsis. Plant Physiol. 2008 Mar;146(3):1267-81. Epub 2008 Jan 9.


In Arabidopsis (Arabidopsis thaliana), the serrated leaf margins formed upon infection resemble the leaf phenotype of transgenic plants with ectopic expression of KNOTTED-like homeobox (KNOX) genes.
1(0,0,0,1) Details
19825007 Singh DP, Filardo FF, Storey R, Jermakow AM, Yamaguchi S, Swain SM: Overexpression of a gibberellin inactivation gene alters seed development, KNOX gene expression, and plant development in Arabidopsis. Physiol Plant. 2010 Jan;138(1):74-90. Epub 2009 Sep 8.

We have examined the role of gibberellins (GAs) in plant development by expression of the pea GA 2-oxidase2 (PsGA2ox2) cDNA, which encodes a GA inactivating enzyme, under the control of the MEDEA (MEA) promoter.
MEA:PsGA2ox2 seedlings had increased expression of the KNOTTED1-like homeobox (KNOX) genes, BP, KNAT2 and KNAT6, which are known to control plant architecture.
1(0,0,0,1) Details
15604716 Kuijt SJ, Lamers GE, Rueb S, Scarpella E, Ouwerkerk PB, Spaink HP, Meijer AH: Different subcellular localization and trafficking properties of KNOX class 1 homeodomain proteins from rice. Plant Mol Biol. 2004 Aug;55(6):781-96.


Genes of the KN1-like homeobox (KNOX) class 1 encode transcription factors involved in shoot apical meristem development and maintenance.
1(0,0,0,1) Details
19567707 Bolduc N, Hake S: The maize transcription factor KNOTTED1 directly regulates the gibberellin catabolism gene ga2ox1. Plant Cell. 2009 Jun;21(6):1647-58. Epub 2009 Jun 30.


KNOTTED1 (KN1)-like homeobox (KNOX) transcription factors are involved in the establishment and maintenance of plant meristems; however, few direct targets of KNOX proteins have been recognized.
1(0,0,0,1) Details
16877025 Shani E, Yanai O, Ori N: The role of hormones in shoot apical meristem function. . Curr Opin Plant Biol. 2006 Oct;9(5):484-9. Epub 2006 Jul 28.


KNOTTED1-like homeobox (KNOX) and WUSCHEL (WUS) transcription factors facilitate high cytokinin activity in the shoot apical meristem (SAM), whereas high gibberellin and auxin activities promote the initiation of lateral organs at specific sites in the SAM flanks.
1(0,0,0,1) Details
16139211 Jasinski S, Piazza P, Craft J, Hay A, Woolley L, Rieu I, Phillips A, Hedden P, Tsiantis M: KNOX action in Arabidopsis is mediated by coordinate regulation of cytokinin and gibberellin activities. Curr Biol. 2005 Sep 6;15(17):1560-5.


Class-I KNOTTED1-like homeobox (KNOX) transcription factors promote meristem function partly through repression of biosynthesis of the growth regulator gibberellin (GA).
1(0,0,0,1) Details
9701574 Kusaba S, Fukumoto M, Honda C, Yamaguchi I, Sakamoto T, Kano-Murakami Y: Decreased GA1 content caused by the overexpression of OSH1 is accompanied by suppression of GA 20-oxidase gene expression. Plant Physiol. 1998 Aug;117(4):1179-84.


We previously reported that overexpression of the rice homeobox gene OSH1 led to altered morphology and hormone levels in transgenic tobacco (Nicotiana tabacum L.) plants.
1(0,0,0,1) Details
17387478 Kim YK, Son O, Kim MR, Nam KH, Kim GT, Lee MS, Choi SY, Cheon CI: ATHB23, an Arabidopsis class I homeodomain-leucine zipper gene, is expressed in the adaxial region of young leaves. Plant Cell Rep. 2007 Aug;26(8):1179-85. Epub 2007 Mar 27.


Homeobox genes are essential regulators of plant development.
1(0,0,0,1) Details
16798950 Kessler S, Townsley B, Sinha N: L1 division and differentiation patterns influence shoot apical meristem maintenance. Plant Physiol. 2006 Aug;141(4):1349-62. Epub 2006 Jun 23.


The class 1 KNOTTED1-like homeobox (KNOX) genes such as knotted1 (kn1) in maize (Zea mays) and SHOOTMERISTEMLESS in Arabidopsis (Arabidopsis thaliana) play a role in maintaining shoot apical meristem indeterminacy, and their misexpression is sufficient to induce cell division and meristem formation.
1(0,0,0,1) Details
11238378 Sakamoto T, Kamiya N, Ueguchi-Tanaka M, Iwahori S, Matsuoka M: KNOX homeodomain protein directly suppresses the expression of a gibberellin biosynthetic gene in the tobacco shoot apical meristem. Genes Dev. 2001 Mar 1;15(5):581-90.


To identify genes targeted by the tobacco KNOX homeodomain protein, Nicotiana tabacum homeobox 15 (NTH15), we have generated an inducible system using the human glucocorticoid receptor.
1(0,0,0,1) Details