Protein Information

Name O GlcNAc
Synonyms GlcNAc transferase; HRNT 1; HRNT1; O GLCNAC; O GlcNAc transferase p110 subunit; O linked GlcNAc transferase isoform 1; O linked N acetylglucosamine transferase; OGT…

Compound Information

Name gibberellins
CAS gibberellins

Reference List

PubMed Abstract RScore(About this table)
17142481 Silverstone AL, Tseng TS, Swain SM, Dill A, Jeong SY, Olszewski NE, Sun TP: Functional analysis of SPINDLY in gibberellin signaling in Arabidopsis. Plant Physiol. 2007 Feb;143(2):987-1000. Epub 2006 Dec 1.


SPY is an O-linked N-acetylglucosamine (GlcNAc) transferase (OGT) with a protein-protein interaction domain consisting of 10 tetratricopeptide repeats (TPR).
1(0,0,0,1) Details
16473894 Hartweck LM, Genger RK, Grey WM, Olszewski NE: SECRET AGENT and SPINDLY have overlapping roles in the development of Arabidopsis thaliana L. J Exp Bot. 2006;57(4):865-75. Epub 2006 Feb 10.


O-GlcNAc transferase (OGT) catalyses transfer of GlcNAc (N-acetylglucosamine) to serine or threonine of proteins.
1(0,0,0,1) Details
19228341 Maymon I, Greenboim-Wainberg Y, Sagiv S, Kieber JJ, Moshelion M, Olszewski N, Weiss D: Cytosolic activity of SPINDLY implies the existence of a DELLA-independent gibberellin-response pathway. Plant J. 2009 Jun;58(6):979-88. Epub 2009 Feb 18.


Coordination of the two pathways involves the O-linked N-acetylglucosamine transferase SPINDLY (SPY) that suppresses GA signaling and promotes cytokinin responses in Arabidopsis.
1(0,0,0,1) Details
19011896 Filardo F, Robertson M, Singh DP, Parish RW, Swain SM: Functional analysis of HvSPY, a negative regulator of GA response, in barley aleurone cells and Arabidopsis. Planta. 2009 Feb;229(3):523-37. Epub 2008 Nov 15.


SPINDLY (SPY) is an important regulator of plant development, and consists of an N-half tetratricopeptide repeat (TPR) domain containing 10 TPR motifs and a C-half catalytic domain, similar to O-GlcNAc transferase (OGT) of animals.
1(0,0,0,1) Details
9634587 Robertson M, Swain SM, Chandler PM, Olszewski NE: Identification of a negative regulator of gibberellin action, HvSPY, in barley. Plant Cell. 1998 Jun;10(6):995-1007.


HvSPY and SPY proteins showed sequence relatedness with animal O-linked N-acetylglucosamine transferases (OGTs), suggesting that they may also have OGT activity.
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11457967 Swain SM, Tseng TS, Olszewski NE: Altered expression of SPINDLY affects gibberellin response and plant development. Plant Physiol. 2001 Jul;126(3):1174-85.

Gibberellins (GAs) are plant hormones with diverse roles in plant growth and development.
SPINDLY (SPY) is one of several genes identified in Arabidopsis that are involved in GA response and it is thought to encode an O-GlcNAc transferase.
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10529823 Thornton TM, Swain SM, Olszewski NE: Gibberellin signal transduction presents ellipsisthe SPY who O-GlcNAc'd me. Trends Plant Sci. 1999 Nov;4(11):424-428.

Although the molecular mechanisms by which plants respond to gibberellins are largely unknown, several components of the signal transduction pathway have been identified and a broad outline of how these components act in signal transduction is emerging.
One component of the pathway, SPINDLY, is believed to be an O-GlcNAc transferase that post-translationally modifies cytosolic and nuclear proteins by the addition of O-linked N-acetylglucosamine.
1(0,0,0,1) Details