Protein Information

Name GA19
Synonyms GA19; Ga19; Gastric cancer antigen Ga19; N terminal acetyltransferase; NARG 1; NARG1; NAT1; NATH…

Compound Information

Name gibberellins
CAS gibberellins

Reference List

PubMed Abstract RScore(About this table)
12223728 Ben-Cheikh W, Perez-Botella J, Tadeo FR, Talon M, Primo-Millo E: Pollination Increases Gibberellin Levels in Developing Ovaries of Seeded Varieties of Citrus. Plant Physiol. 1997 Jun;114(2):557-564.

Reproductive and vegetative tissues of the seeded Pineapple cultivars of sweet orange (Citrus sinensis L.) contained the following C-13 hydroxylated gibberellins (GAs): GA53, GA17, GA19, GA20, GA1, GA29, and GA8, as well as GA97, 3-epi-GA1, and several uncharacterized GAs.
32(0,1,1,2) Details
12009314 Huntley RP, Jones LH, Hanke DE: Cytokinins and gibberellins in sap exudate of the oil palm. Phytochemistry. 2002 May;60(2):117-27.

The most abundant gibberellins identified in exudates were GA19 and GA44, as well as other members of the early 13-hydroxylation pathway.
31(0,1,1,1) Details
15821147 Lee DJ, Zeevaart JA: Molecular cloning of GA 2-oxidase3 from spinach and its ectopic expression in Nicotiana sylvestris. Plant Physiol. 2005 May;138(1):243-54. Epub 2005 Apr 8.

Previous work has shown that 13-hydroxylated gibberellins (GAs) are predominant in the long-day (LD) plant spinach (Spinacia oleracea; GA53, GA44, GA19, GA20, GA1, GA8, and GA29).
31(0,1,1,1) Details
8987503 Mander LN, Owen DJ, Croker SJ, Gaskin P, Hedden P, Lewis MJ, Talon M, Gage DA, Zeevaart JA, Brenner ML, Sheng C: Identification of three C20-gibberellins: GA97 (2 beta-hydroxy-GA53), GA98 (2 beta-hydroxy-GA44) and GA99 (2 beta-hydroxy-GA19). Phytochemistry. 1996 Sep;43(1):23-8.
12(0,0,2,2) Details
12226373 Sponsel VM, Ross JJ, Reynolds MR, Symons GM, Reid JB: The Gibberellin Status of lip1, a Mutant of Pea That Exhibits Light-Independent Photomorphogenesis. Plant Physiol. 1996 Sep;112(1):61-66.

The involvement of gibberellins (GAs) with the mutant phenotype was examined by applying GA1 and GA20 to the mutant and WT, and by quantifying endogenous GA1, GA8, GA19, GA20, and GA29 levels in the two genotypes.
8(0,0,1,3) Details
11117879 Kobayashi M, MacMillan J, Phinney B, Gaskin P, Spray CR, Hedden P: Gibberellin biosynthesis: metabolic evidence for three steps in the early 13-hydroxylation pathway of rice. Phytochemistry. 2000 Oct;55(4):317-21.

[14C4] GA53, [14C4] GA44, and [2H2/14C4] GA19 were injected separately into seedlings of rice (Oryza sativa) using a dwarf mutant (d35) that has low levels of endogenous gibberellins (GAs).
7(0,0,1,2) Details
10731033 Blake PS, Browning G, Benjamin LJ, Mander LN: Gibberellins in seedlings and flowering trees of Prunus avium L. Phytochemistry. 2000 Feb;53(4):519-28.

The presence of the known gibberellins (GAs) GA1 (1), GA3 (4), GA5 (7), GA8 (11), GA19 (14), GA20 (12), GA29 (13), GA32 (5), GA85 (2), GA86 (3) and GA87 (6) was confirmed by comparison of their mass spectra and Kovats retention indices with those of standards or literature values.
7(0,0,1,2) Details
17080953 Kurepin LV, Pharis RP, Reid DM, Chinnappa CC: Involvement of gibberellins in the stem elongation of sun and shade ecotypes of Stellaria longipes that is induced by low light irradiance. Plant Cell Environ. 2006 Jul;29(7):1319-28.

When quantified by the stable isotope dilution method, endogenous gibberellins (GAs) (GA1, GA8, GA20, GA19) were significantly elevated under low PAR in both 'sun' and 'shade' ecotypes, as was GA53 in the shade ecotype.
7(0,0,1,2) Details
11140520 Blake PS, Taylor DR, Crisp CM, Mander LN, Owen DJ: Identification of endogenous gibberellins in strawberry, including the novel gibberellins GA123, GA124 and GA125. Phytochemistry. 2000 Dec;55(8):887-90.

The following previously characterised gibberellins were identified by comparison of their mass spectra and Kovats retention indices (KRIs) with those of standards or published data: GA1, GA3, GA5, GA8, GA12, GA17, GA19, GA20, GA29, GA44, GA48, GA49, GA53, GA77, GA97, GA111 and GA112.
7(0,0,1,2) Details
19099608 Khan SA, Hamayun M, Yoon H, Kim HY, Suh SJ, Hwang SK, Kim JM, Lee IJ, Choo YS, Yoon UH, Kong WS, Lee BM, Kim JG: Plant growth promotion and Penicillium citrinum. BMC Microbiol. 2008 Dec 22;8:231.

Analysis of the culture filtrate of IR-3-3 showed the presence of physiologically active gibberellins, GA1, GA3, GA4 and GA7 (1.95 ng/ml, 3.83 ng/ml, 6.03 ng/ml and 2.35 ng/ml, respectively) along with other physiologically inactive GA5, GA9, GA12, GA15, GA19, GA20 and, GA24.
6(0,0,1,1) Details
19763416 Hamayun M, Khan SA, Iqbal I, Na CI, Khan AL, Hwang YH, Lee BH, Lee IJ: Chrysosporium pseudomerdarium produces gibberellins and promotes plant growth. J Microbiol. 2009 Aug;47(4):425-30. Epub 2009 Sep 9.

The D-2-1 culture filtrate (CF) was analyzed for the presence of gibberellins (GAs) and it was observed that all physiologically active GAs, especially gibberellic acid, were present in higher amounts (GA1, 0.24 ng/ml; GA3, 8.99 ng/ml; GA4, 2.58 ng/ml and GA7, 1.39 ng/ml) in conjunction with physiologically inactive GA5, GA9, GA15, GA19, and GA24.
6(0,0,1,1) Details
20134253 Hamayun M, Khan SA, Iqbal I, Ahmad B, Lee IJ: Isolation of a Gibberellin-producing fungus (Penicillium sp. J Microbiol Biotechnol. 2010 Jan;20(1):202-7.

The MH7 CF was analyzed for gibberellins and it contained all physiologically active gibberellins (GA1, 1.37 ng/ml; GA3, 5.88 ng/ml; GA4, 8.62 ng/ml and GA7, 2.05 ng/ml) in conjunction with physiologically inactive GA9 (0.83 ng/ml), GA12 (0.44 ng/ml), GA15 (0.74 ng/ml), GA19 (1.16 ng/ml) and GA20 (0.98 ng/ml).
6(0,0,1,1) Details
8904804 Martin DN, Proebsting WM, Parks TD, Dougherty WG, Lange T, Lewis MJ, Gaskin P, Hedden P: Feed-back regulation of gibberellin biosynthesis and gene expression in Pisum sativum L. Planta. 1996;200(2):159-66.


Treatment of tall and dwarf (3 beta-hydroxylase impaired) genotypes of pea (Pisum sativum L.) with the synthetic, highly active gibberellin (GA), 2,2-dimethyl GA4, reduced the shoot contents of C19-GAs, including GA1, and increased the concentration of the C20-GA, GA19.
4(0,0,0,4) Details
15022829 Suttle JC: Involvement of endogenous gibberellins in potato tuber dormancy and early sprout growth: a critical assessment. J Plant Physiol. 2004 Feb;161(2):157-64.

Immediately after harvest, the endogenous contents of GA19, GA20, and GA1 were relatively high (0.48-0.62 ng g fresh weight (-1)).
4(0,0,0,4) Details
8539289 van Huizen R, Ozga JA, Reinecke DM, Twitchin B, Mander LN: Seed and 4-chloroindole-3-acetic acid regulation of gibberellin metabolism in pea pericarp. Plant Physiol. 1995 Dec;109(4):1213-7.


In this study, we investigated seed and auxin regulation of gibberellin (GA) biosynthesis in pea (Pisum sativum L.) pericarp tissue in situ, specifically the conversion of [14C] GA19 to [14C] GA20. [14C] GA19 metabolism was monitored in pericarp with seeds, deseeded pericarp, and deseeded pericarp treated with 4-chloroindole-3-acetic acid (4-CI-IAA).
3(0,0,0,3) Details
12231850 Ross JJ, Murfet IC, Reid JB: Distribution of Gibberellins in Lathyrus odoratus L. and Their Role in Leaf Growth. Plant Physiol. 1993 Jun;102(2):603-608.

Rapidly expanding internodes contained much more gibberellin A19 (GA19) than gibberellin A20 (GA20), whereas the opposite was true for expanding leaflets.
3(0,0,0,3) Details
12231827 Nilsson O, Moritz T, Imbault N, Sandberg G, Olsson O: Hormonal Characterization of Transgenic Tobacco Plants Expressing the rolC Gene of Agrobacterium rhizogenes TL-DNA. Plant Physiol. 1993 Jun;102(2):363-371.

The biggest difference between rolC and wild-type plants was in the concentrations of the cytokinin, isopentenyladenosine (iPA) and the gibberellin GA19.
Thus, we conclude that RolC activity in transgenic plants leads to major alterations in the metabolism of cytokinins and gibberellins.
2(0,0,0,2) Details
12228498 Zanewich KP, Rood SB: Vernalization and Gibberellin Physiology of Winter Canola (Endogenous Gibberellin (GA) Content and Metabolism of [3H] GA1 and [3H] GA20. Plant Physiol. 1995 Jun;108(2):615-621.

To investigate the role of gibberellins (GAs) in vernalization-induced events, endogenous GA content and the metabolism of [3H] GAs were examined in 10-week vernalized and nonvernalized plants.
Concentrations of GA1, GA3, GA8, GA19, and GA20 were 3.1-, 2.3-, 7.8-, 12.0-, and 24.5-fold higher, respectively, in the vernalized plants at the end of the vernalization treatment (0 DPV) relative to the nonvernalized plants.
2(0,0,0,2) Details
11941469 Eriksson ME, Moritz T: Daylength and spatial expression of a gibberellin 20-oxidase isolated from hybrid aspen (Populus tremula L. x P. tremuloides Michx.). Planta. 2002 Apr;214(6):920-30. Epub 2001 Dec 15.

Upon transfer to SDs an accumulation of GA19 was observed in early elongating internodes and leaf blades.
Physiologically active gibberellins (GAs) are key regulators of shoot growth in trees.
2(0,0,0,2) Details
11473701 Chang ST, Chen WS, Koshioka M, Mander LN, Huang KL, Du BS: Gibberellins in relation to flowering in Polianthes tuberosa. Physiol Plant. 2001 Jul;112(3):429-432.

An increase in GA1 and GA20, and a decrease in GA19 levels, coincided with the transition from the vegetative phase to the stages of early floral initiation and flower development.
1(0,0,0,1) Details
11867101 Pearce DW, Hutt OE, Rood SB, Mander LN: Gibberellins in shoots and developing capsules of Populus species. Phytochemistry. 2002 Mar;59(6):679-87.

The following known GAs were identified by comparison of their Kovats retention indices (KRIs) and mass spectra with those of standards: GA1, GA8, GA9, GA19, GA20, 16 beta,17-dihydro-17-hydroxy GA20, GA23, GA28, GA29, GA34, GA44, and GA97.
1(0,0,0,1) Details
8742334 Wu K, Li L, Gage DA, Zeevaart JA: Molecular cloning and photoperiod-regulated expression of gibberellin 20-oxidase from the long-day plant spinach. Plant Physiol. 1996 Feb;110(2):547-54.

Spinach (Spinacia oleracea L.) is a long-day (LD) rosette plant in which stem growth under LD conditions is mediated by gibberellins (GAs).
When this cDNA clone was expressed in Escherichia coli, the fusion protein catalyzed the biosynthetic sequence GA53--> GA44--> GA19--> GA20 and GA19--> GA17.
1(0,0,0,1) Details
2236013 Talon M, Koornneef M, Zeevaart JA: Endogenous gibberellins in Arabidopsis thaliana and possible steps blocked in the biosynthetic pathways of the semidwarf ga4 and ga5 mutants. Proc Natl Acad Sci U S A. 1990 Oct;87(20):7983-7.

Eight of them are members of the early-13-hydroxylation pathway (GA53, GA44, GA19, GA17, GA20, GA1, GA29, and GA8), six are members of the early-3-hydroxylation pathway (GA37, GA27, GA36, GA13, GA4, and GA34), and the remaining six are members of the non-3,13-hydroxylation pathway (GA12, GA15, GA24, GA25, GA9, and GA51).
1(0,0,0,1) Details
17543977 Ge L, Peh CY, Yong JW, Tan SN, Hua L, Ong ES: Analyses of gibberellins by capillary electrophoresis-mass spectrometry combined with solid-phase extraction. J Chromatogr A. 2007 Aug 3;1159(1-2):242-9. Epub 2007 May 17.

Under optimum conditions, a baseline separation of 11 GAs, including GA1, GA3, GA4, GA5, GA6, GA7, GA13, GA19, GA20, GA24 and GA53 was accomplished within 25 min using 70 mM ammonium formate/formic acid buffer (pH 3.8) and 2% (v/v) acetonitrile with -25 kV as the separation voltage.
1(0,0,0,1) Details
15605238 Jager CE, Symons GM, Ross JJ, Smith JJ, Reid JB: The brassinosteroid growth response in pea is not mediated by changes in gibberellin content. Planta. 2005 Apr;221(1):141-8. Epub 2004 Dec 17.

The objective of this study was to increase our understanding of the relationship between brassinosteroids (BRs) and gibberellins (GAs) by examining the effects of BR deficiency on the GA biosynthesis pathway in several tissue types of pea (Pisum sativum L.).
The application of brassinolide (BL) to lkb plants reduced GA20 levels, and metabolism studies revealed a reduced conversion of GA19 to GA20 in epi-BL-treated lkb plants.
1(0,0,0,1) Details
11762165 Wolbang CM, Ross JJ: Auxin promotes gibberellin biosynthesis in decapitated tobacco plants. Planta. 2001 Nov;214(1):153-7.


Decapitation reduced the conversion of [14C] GA19 to [14C] GA20 and of [14C] GA20 to [14C] GA1, and appeared to promote the deactivation pathway [14C] GA20 to [14C] GA29 to [14C] GA29-catabolite.
1(0,0,0,1) Details
9750350 Tanaka-Ueguchi M, Itoh H, Oyama N, Koshioka M, Matsuoka M: Over-expression of a tobacco homeobox gene, NTH15, decreases the expression of a gibberellin biosynthetic gene encoding GA 20-oxidase. Plant J. 1998 Aug;15(3):391-400.


Quantitative analysis of intermediates in the GA biosynthetic pathway revealed that the step from GA19 to GA20 was blocked in transgenic tobacco plants overexpressing NTH15.
1(0,0,0,1) Details
11299021 Fos M, Proano K, Nuez F, Garcia-Martinez JL: Role of gibberellins in parthenocarpic fruit development induced by the genetic system pat-3/pat-4 in tomato. Physiol Plant. 2001 Apr;111(4):545-550.

The quantification of the main GAs of the early 13-hydroxylation pathway (GA1, GA8, GA19, GA20, GA29 and GA44) in unpollinated ovaries at 3 developmental stages (flower bud, FB; pre-anthesis, PR; and anthesis, AN), by gas chromatography-selected ion monitoring, showed that the concentration of most of them was higher in pat-3/pat-4 than in WT ovaries at PR and AN stages.
1(0,0,0,1) Details
11539033 Rood SB, Kaufman PB, Abe H, Pharis RP: Gibberellins and gravitropism in maize shoots: endogenous gibberellin-like substances and movement and metabolism of [3H] Gibberellin A20. Plant Physiol. 1987;83:645-51.

The qualitative elution profile of GA-like substances differed consistently, upper halves containing principally a GA20-like substance and lower halves containing principally a GA20-like substance and lower halves containing mainly GA1-like and GA19-like substances.
1(0,0,0,1) Details
8078921 Lange T, Hedden P, Graebe JE: Expression cloning of a gibberellin 20-oxidase, a multifunctional enzyme involved in gibberellin biosynthesis. Proc Natl Acad Sci U S A. 1994 Aug 30;91(18):8552-6.

In the biosynthetic pathway to the gibberellins (GAs), carbon-20 is removed by oxidation to give the C19-GAs, which include the biologically active plant hormones.
Recombinant protein from a selected clone catalyzed the three-step conversions of GA12 to GA25 and of GA53 to GA17, as well as the formation of the C19-GAs, GA1, GA9, and GA20, from their respective aldehyde precursors, GA23, GA24, and GA19.
1(0,0,0,1) Details
7604047 Xu YL, Li L, Wu K, Peeters AJ, Gage DA, Zeevaart JA: The GA5 locus of Arabidopsis thaliana encodes a multifunctional gibberellin 20-oxidase: molecular cloning and functional expression. Proc Natl Acad Sci U S A. 1995 Jul 3;92(14):6640-4.

The biosynthesis of gibberellins (GAs) after GA12-aldehyde involves a series of oxidative steps that lead to the formation of bioactive GAs.
A cDNA clone corresponding to the putative GA 20-oxidase genomic sequence was constructed with the reverse transcription-PCR method, and the identity of the cDNA clone was confirmed by analyzing the capability of the fusion protein expressed in Escherichia coli to convert GA53 to GA44 and GA19 to GA20.
1(0,0,0,1) Details
9701574 Kusaba S, Fukumoto M, Honda C, Yamaguchi I, Sakamoto T, Kano-Murakami Y: Decreased GA1 content caused by the overexpression of OSH1 is accompanied by suppression of GA 20-oxidase gene expression. Plant Physiol. 1998 Aug;117(4):1179-84.


The internal GA1 and GA20 contents in OSH1-transformed tobacco were dramatically reduced compared with those of wild-type plants, whereas the level of GA19, a mid-product of GA 20-oxidase, was 25% of the wild-type level.
1(0,0,0,1) Details
16160850 Appleford NE, Evans DJ, Lenton JR, Gaskin P, Croker SJ, Devos KM, Phillips AL, Hedden P: Function and transcript analysis of gibberellin-biosynthetic enzymes in wheat. Planta. 2006 Feb;223(3):568-82. Epub 2005 Sep 14.


The intermediate GA19 has an especially low affinity for the enzyme, consistent with its accumulation in wheat tissues.
1(0,0,0,1) Details
12223795 Van Huizen R, Ozga JA, Reinecke DM: Seed and Hormonal Regulation of Gibberellin 20-Oxidase Expression in Pea Pericarp. Plant Physiol. 1997 Sep;115(1):123-128.

To understand further how seeds, auxin (4-chloroindole-3-acetic acid [4-Cl-IAA]), and gibberellins (GAs) regulate GA biosynthesis in pea (Pisum sativum L.) pericarp at the molecular level, we studied the expression of GA 20-oxidase in this tissue using northern-blot analysis.
These data suggest that the previously reported conversion of GA19 to GA20 in pea pericarp is controlled by seeds, 4-Cl-IAA, and GA3 at least in part by regulating GA 20-oxidase mRNA levels in this tissue.
1(0,0,0,1) Details