| Name | thrombin |
|---|---|
| Synonyms | Coagulation factor II; Coagulation factor II variant; F2; F2 protein; F2 protein precursor; Factor II; PT; Prothrombin… |
| Name | sodium chlorate |
|---|---|
| CAS | sodium chlorate |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 8204629 | Pittman DD, Tomkinson KN, Michnick D, Selighsohn U, Kaufman RJ: Posttranslational sulfation of factor V is required for efficient thrombin cleavage and activation and for full procoagulant activity. Biochemistry. 1994 Jun 7;33(22):6952-9. The importance of sulfation for factor V secretion and activity was evaluated by characterizing factor V expressed in Chinese hamster ovary cells grown in the presence of sodium chlorate, a potent inhibitor of posttranslational sulfation in intact cells. |
5(0,0,0,5) | Details |
| 9221767 | Tolar M, Marques MA, Harmony JA, Crutcher KA: Neurotoxicity of the 22 kDa thrombin-cleavage fragment of apolipoprotein E and related synthetic peptides is receptor-mediated. J Neurosci. 1997 Aug 1;17(15):5678-86. Effective inhibitors of neurotoxicity of both the apoE peptides and the apoE fragment include heparan sodium chlorate and heparinase, the low-density lipoprotein (LDL) receptor-related protein receptor-associated protein, and a polyclonal anti-LDL receptor-related protein antibody. |
3(0,0,0,3) | Details |
| 9164657 | Wilkins-Port CE, McKeown-Longo PJ: Heparan sulfate proteoglycans function in the binding and degradation of vitronectin by fibroblast monolayers. Biochem Cell Biol. 1996;74(6):887-97. In addition to its role in adhesion, matrix vitronectin is also believed to function as an opsonin promoting the clearance of thrombin-serpin complexes from the matrix. Sodium chlorate, a competitive inhibitor of proteoglycan sulfation, produced a dose-dependent decrease in both binding and degradation of vitronectin. |
1(0,0,0,1) | Details |
| 15566360 | Rodriguez MH, Plantier JL, Enjolras N, Rea M, Leboeuf M, Uzan G, Negrier C: Biosynthesis of FVIII in megakaryocytic cells: improved production and biochemical characterization. Br J Haematol. 2004 Dec;127(5):568-75. This recombinant FVIII protein exhibited biochemical characteristics after deglycosylation or thrombin activation that were comparable to a commercially available B-domainless rFVIII. |
1(0,0,0,1) | Details |
| 1554716 | Pittman DD, Wang JH, Kaufman RJ: Identification and functional importance of residues within recombinant factor VIII. Biochemistry. 1992 Apr 7;31(13):3315-25. However, factor VIII secreted in the presence of sodium chlorate exhibited a 5-fold reduction in procoagulant activity, although the protein was susceptible to thrombin cleavage. |
83(1,1,1,3) | Details |
| 15144459 | Feistritzer C, Kaneider NC, Sturn DH, Wiedermann CJ: Syndecan-4-dependent migration of human eosinophils. . Clin Exp Allergy. 2004 May;34(5):696-703. The effects of anti-thrombin III were abolished by pre-treating cells with heparinase-1, chondroitinase, sodium chlorate and anti-syndecan-4 antibodies. |
13(0,0,1,8) | Details |