Protein Information

Name alkaline phosphatase
Synonyms ALP 1; Alkaline phosphatase; ALPG; ALPPL; ALPPL 2; ALPPL2; GCAP; Germ cell alkaline phosphatase…

Compound Information

Name sodium chlorate
CAS sodium chlorate

Reference List

PubMed Abstract RScore(About this table)
19804635 Osses N, Casar JC, Brandan E: Inhibition of extracellular matrix assembly induces the expression of osteogenic markers in skeletal muscle cells by a BMP-2 independent mechanism. BMC Cell Biol. 2009 Oct 5;10:73.

RESULTS: Inhibition of proteoglycan sulfation by sodium chlorate in myoblast cultures strongly affects ECM synthesis and deposition and induces the expression of the osteogenic lineage markers alkaline phosphatase (ALP) and osteocalcin in mononuclear cells.
81(1,1,1,1) Details
8501463 Poe RW, Sangadala VS, Brewer JM: Effects of various salts on the steady-state enzymatic activity of E. coli alkaline phosphatase. J Inorg Biochem. 1993 May 15;50(3):173-80.

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9409283 Lupu C, Goodwin CA, Westmuckett AD, Emeis JJ, Scully MF, Kakkar VV, Lupu F: Tissue factor pathway inhibitor in endothelial cells colocalizes with glycolipid microdomains/caveolae. Arterioscler Thromb Vasc Biol. 1997 Nov;17(11):2964-74.


After ultracentrifugation of rat lung or EC homogenates through density gradients of Nycodenz, TFPI was highly enriched at densities of 1.05 to 1.08 g/mL, together with caveolin and alkaline phosphatase.
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7840621 Chintala SK, Miller RR, McDevitt CA: Role of heparan sulfate in the terminal differentiation of growth plate chondrocytes. Arch Biochem Biophys. 1995 Jan 10;316(1):227-34.

Treatment of growth plate chondrocytes with sodium chlorate, a reversible inhibitor of glycosaminoglycan sulfation, resulted in terminal differentiation of growth plate chondrocytes even in the presence of bFGF at concentrations that normally repress their differentiation.
Chlorate treatment in the presence of bFGF resulted in an increase in alkaline phosphatase activity and a decrease in cellular proliferation, both characteristics of the differentiated state.
1(0,0,0,1) Details