| Name | heparan sulfate proteoglycans |
|---|---|
| Synonyms | Fibroglycan; HSPG; HSPG 1; HSPG1; Heparan sulfate proteoglycan; Heparan sulfate proteoglycan 1 cell surface associated fibroglycan; Heparan sulfate proteoglycan core protein; SDC 2… |
| Name | sodium chlorate |
|---|---|
| CAS | sodium chlorate |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17081280 | Djanani A, Mosheimer B, Kaneider NC, Ross CR, Ricevuti G, Patsch JR, Wiedermann CJ: Heparan sulfate proteoglycan-dependent neutrophil chemotaxis toward PR-39 cathelicidin. J Inflamm. 2006 Nov 2;3:14. Modification of heparan sulfate proteoglycans with sodium chlorate inhibited migration whereas chemotaxis toward the chemoattractant formyl-Met-- was not affected. Involvement of heparan sulfate proteoglycans was tested by their chemical modification and by the use of specific antibodies. |
2(0,0,0,2) | Details |
| 17020882 | Jiao X, Billings PC, O'Connell MP, Kaplan FS, Shore EM, Glaser DL: Heparan sulfate proteoglycans (HSPGs) modulate BMP2 osteogenic bioactivity in C2C12 cells. J Biol Chem. 2007 Jan 12;282(2):1080-6. Epub 2006 Oct 3. Depletion of cell surface HSPGs by heparinase III treatment or decreased glycosaminoglycan chain sulfation with sodium chlorate enhances BMP2 morpho-genetic bioactivity. |
2(0,0,0,2) | Details |
| 9748322 | Sperinde GV, Nugent MA: Heparan sulfate proteoglycans control intracellular processing of bFGF in vascular smooth muscle cells. Biochemistry. 1998 Sep 22;37(38):13153-64. HSPG-deficient VSMC were generated by treating cells with sodium chlorate to inhibit the sulfation of HSPG. |
2(0,0,0,2) | Details |
| 19812150 | Kalia M, Chandra V, Rahman SA, Sehgal D, Jameel S: Heparan sulfate proteoglycans are required for cellular binding of the hepatitis E virus ORF2 capsid protein and for viral infection. J Virol. 2009 Dec;83(24):12714-24. Epub 2009 Oct 7. Removal of cell surface by enzymatic (heparinase) or chemical (sodium chlorate) treatment of cells or competition with and their oversulfated derivatives caused a marked reduction in pORF2 binding to the cells. |
2(0,0,0,2) | Details |
| 9164657 | Wilkins-Port CE, McKeown-Longo PJ: Heparan sulfate proteoglycans function in the binding and degradation of vitronectin by fibroblast monolayers. Biochem Cell Biol. 1996;74(6):887-97. Sodium chlorate, a competitive inhibitor of proteoglycan sulfation, produced a dose-dependent decrease in both binding and degradation of vitronectin. |
2(0,0,0,2) | Details |
| 11856308 | Brucato S, Bocquet J, Villers C: Cell surface heparan sulfate proteoglycans: target and partners of the basic fibroblast growth factor in rat Sertoli cells. Eur J Biochem. 2002 Jan;269(2):502-11. Indeed, sodium chlorate, described to drastically decrease proteoglycan sulfation, abolishes the bFGF downregulation of FSH-stimulated synthesis previously observed. |
2(0,0,0,2) | Details |
| 10736179 | Sperinde GV, Nugent MA: Mechanisms of fibroblast growth factor 2 intracellular processing: a kinetic analysis of the role of heparan sulfate proteoglycans. Biochemistry. 2000 Apr 4;39(13):3788-96. HSPG-deficient cells were generated by treatment with sodium chlorate. |
2(0,0,0,2) | Details |
| 1484387 | Kallapur SG, Akeson RA: The neural cell adhesion molecule (NCAM) binding domain binds to cell surface heparan sulfate proteoglycans. J Neurosci Res. 1992 Dec;33(4):538-48. Furthermore, inhibition of HSPG sulfation with sodium chlorate also decreased the adhesion of B35 cells to the HBD peptide. |
2(0,0,0,2) | Details |
| 11562534 | Song BH, Lee GC, Moon MS, Cho YH, Lee CH: Human cytomegalovirus binding to heparan sulfate proteoglycans on the cell surface and/or entry stimulates the expression of human leukocyte antigen class I. J Gen Virol. 2001 Oct;82(Pt 10):2405-13. Sodium chlorate, which is known to inhibit the sulfation of HSPGs, gave a similar result. |
2(0,0,0,2) | Details |
| 14705951 | Kaneider NC, Dunzendorfer S, Wiedermann CJ: Heparan sulfate proteoglycans are involved in opiate receptor-mediated cell migration. Biochemistry. 2004 Jan 13;43(1):237-44. Chemotactic properties were abolished by pretreating cells with heparinase, chondroitinase, sodium chlorate, and anti-syndecan-4 antibodies, indicating the involvement of syndecan-4. |
2(0,0,0,2) | Details |
| 12761845 | Ford-Perriss M, Turner K, Guimond S, Apedaile A, Haubeck HD, Turnbull J, Murphy M: Localisation of specific heparan sulfate proteoglycans during the proliferative phase of brain development. Dev Dyn. 2003 Jun;227(2):170-84. We find that FGF2 stimulation of proliferation is inhibited in the presence of sodium chlorate, an inhibitor of synthesis, and is rescued by addition of exogenous |
1(0,0,0,1) | Details |
| 11549250 | Kaneider NC, Egger P, Dunzendorfer S, Wiedermann CJ: Syndecan-4 as antithrombin receptor of human neutrophils. . Biochem Biophys Res Commun. 2001 Sep 14;287(1):42-6. Mechanisms of antithrombin's effects on neutrophils were, therefore, studied by testing function and expression of heparan sulfate proteoglycans in RT-PCR or flow cytometry and cell migration assays, respectively. In vitro effects of antithrombin on human neutrophil migration in modified Boyden chambers were abolished by pretreating cells with heparinase-1, chondroitinase, sodium chlorate, and anti-syndecan-4 antibodies. |
1(0,0,0,1) | Details |
| 7528211 | Reich-Slotky R, Bonneh-Barkay D, Shaoul E, Bluma B, Svahn CM, Ron D: Differential effect of cell-associated heparan sulfates on the binding of keratinocyte growth factor (KGF) and acidic fibroblast growth factor to the KGF receptor. J Biol Chem. 1994 Dec 23;269(51):32279-85. Treatment of cells with sodium chlorate, which blocks sulfation of proteoglycans, reduced the binding of aFGF to its low and high affinity binding sites by 95 and 80%, respectively. The fibroblast growth factors (FGFs) act through high affinity tyrosine kinase receptors and, in addition, interact with lower affinity receptors that represent cell- or matrix-associated heparan sulfate proteoglycans. |
1(0,0,0,1) | Details |
| 12867431 | Barth H, Schafer C, Adah MI, Zhang F, Linhardt RJ, Toyoda H, Kinoshita-Toyoda A, Toida T, Van Kuppevelt TH, Depla E, Von Weizsacker F, Blum HE, Baumert TF: Cellular binding of hepatitis C virus envelope glycoprotein E2 requires cell surface J Biol Chem. 2003 Oct 17;278(42):41003-12. Epub 2003 Jul 16. Using recombinant envelope glycoprotein E2 and virus-like particles as ligands for cellular binding, we demonstrate that cell surface heparan sulfate proteoglycans (HSPG) play an important role in mediating HCV envelope-target cell interaction. |
1(0,0,0,1) | Details |
| 9144091 | Seo T, St Clair RW: Heparan sulfate proteoglycans mediate internalization and degradation of beta-VLDL and promote accumulation by pigeon macrophages. J Lipid Res. 1997 Apr;38(4):765-79. |
1(0,0,0,1) | Details |
| 14684735 | Gao R, Brigstock DR: Connective tissue growth factor (CCN2) induces adhesion of rat activated hepatic stellate cells by binding of its C-terminal domain to integrin alpha (v) beta (3) and heparan sulfate proteoglycan. J Biol Chem. 2004 Mar 5;279(10):8848-55. Epub 2003 Dec 17. In this study we show that rat activated HSC are capable of adhesion to all three CCN2 isoforms via the binding of module 4 to integrin alpha (v) beta (3), a process that is dependent on interactions between module 4 and cell surface heparan sulfate proteoglycans (HSPGs). Third, destruction or inhibition of synthesis of cell surface HSPGs with, respectively, heparinase or sodium chlorate abrogated HSC adhesion to CCN2 (4). |
1(0,0,0,1) | Details |
| 11463464 | Jacquet A, Coulon L, De Neve J, Daminet V, Haumont M, Garcia L, Bollen A, Jurado M, Biemans R: The surface antigen SAG3 mediates the attachment of Toxoplasma gondii to cell-surface proteoglycans. Mol Biochem Parasitol. 2001 Aug;116(1):35-44. The attachment of Toxoplasma gondii to target cells is mediated by recognition of cellular heparan sulfate proteoglycans (HSPGs). Proteoglycan sulfation was critical for SAG3 adherence to HSPGs as incubation of cells in the presence of sodium chlorate drastically reduced the recSAG3 binding. |
1(0,0,0,1) | Details |
| 8663512 | Fannon M, Nugent MA: Basic fibroblast growth factor binds its receptors, is internalized, and stimulates DNA synthesis in Balb/c3T3 cells in the absence of J Biol Chem. 1996 Jul 26;271(30):17949-56. We have investigated the interaction of basic fibroblast growth factor (bFGF) with its receptors and heparan sulfate proteoglycans (HSPG). In our studies, Balb/c3T3 fibroblasts were treated with 50 mM sodium chlorate to completely inhibit (99%) sulfation of proteoglycans. |
1(0,0,0,1) | Details |
| 11801740 | Kaneider NC, Reinisch CM, Dunzendorfer S, Romisch J, Wiedermann CJ: Syndecan-4 mediates antithrombin-induced chemotaxis of human peripheral blood lymphocytes and monocytes. J Cell Sci. 2002 Jan 1;115(Pt 1):227-36. Effects of antithrombin were abolished by pretreating cells with heparinase-1, chondroitinase, sodium chlorate and anti-syndecan-4 antibodies. Expression of heparan sulfate proteoglycan core protein was studied by RT-PCR and flow cytometry. |
1(0,0,0,1) | Details |
| 10684625 | Fannon M, Forsten KE, Nugent MA: Potentiation and inhibition of bFGF binding by a model for regulation of cellular response. Biochemistry. 2000 Feb 15;39(6):1434-45. Basic fibroblast growth factor (bFGF) binds to cell surface tyrosine kinase receptor proteins and to heparan sulfate proteoglycans. Balb/c3T3 cells were treated with various concentrations of sodium chlorate, so as to express a range of endogenous sites, and [(125) I] bFGF binding was assessed in the presence of a range of concentrations. |
1(0,0,0,1) | Details |
| 9278150 | Schriever C, Breithardt G, Schmidt A: Undersulfation of proteoheparan stimulates the expression of basic fibroblast growth factor and protein synthesis but suppresses replication of coronary smooth muscle cells. Biol Chem. 1997 Jul;378(7):701-6. Heparan sulfate proteoglycans are obligatory for receptor binding and mitogenic activity of the basic fibroblast growth factor (bFGF). When cultured cSMC were treated with 10 mM sodium chlorate in -depleted medium, the cell number and [3H] incorporation decreased by 76% and 66% respectively, while the protein content per cell was doubled. |
1(0,0,0,1) | Details |
| 14585398 | Gao R, Brigstock DR: Low density lipoprotein receptor-related protein (LRP) is a -dependent adhesion receptor for connective tissue growth factor (CTGF) in rat activated hepatic stellate cells. Hepatol Res. 2003 Nov;27(3):214-220. Co-incubation of CTGF with or perturbation of cell surface HSPGs with heparinase or sodium chlorate completely blocked adhesion of activated HSCs to all CTGF isoforms. |
0(0,0,0,0) | Details |
| 12810721 | Fuki IV, Blanchard N, Jin W, Marchadier DH, Millar JS, Glick JM, Rader DJ: Endogenously produced endothelial lipase enhances binding and cellular processing of plasma lipoproteins via heparan sulfate proteoglycan-mediated pathway. J Biol Chem. 2003 Sep 5;278(36):34331-8. Epub 2003 Jun 16. In summary, EL mediates binding and uptake of plasma lipoproteins via a process that is independent of its enzymatic activity, requires cellular heparan sulfate proteoglycans, and is regulated by ligand clustering. Inhibition of proteoglycan sulfation by sodium chlorate or incubation of cells with labeled lipoproteins in the presence of (100 microg/ml) abolished bridging effects of EL. |
1(0,0,0,1) | Details |
| 15292202 | Gingis-Velitski S, Zetser A, Kaplan V, Ben-Zaken O, Cohen E, Levy-Adam F, Bashenko Y, Flugelman MY, Vlodavsky I, Ilan N: Heparanase uptake is mediated by cell membrane heparan sulfate proteoglycans. J Biol Chem. 2004 Oct 15;279(42):44084-92. Epub 2004 Jul 29. Addition of or xylosides to cell cultures resulted in a pronounced accumulation of, heparanase in the culture medium, whereas sodium chlorate had no such effect. |
1(0,0,0,1) | Details |
| 1646484 | Rapraeger AC, Krufka A, Olwin BB: Requirement of for bFGF-mediated fibroblast growth and myoblast differentiation. Science. 1991 Jun 21;252(5013):1705-8. Basic fibroblast growth factor (bFGF) binds to heparan sulfate proteoglycans at the cell surface and to receptors with kinase activity. |
1(0,0,0,1) | Details |
| 11262187 | Borgenstrom M, Tienhaara A, Spillmann D, Salmivirta M, Jalkanen M: -induced growth of S115 mouse mammary tumor cells is dependent on Exp Cell Res. 2001 Apr 1;264(2):307-14. We demonstrate that when the cells are treated with sodium chlorate, which inhibits the sulfation of endogenous heparan sulfate proteoglycans, cell growth becomes dependent on exogenous |
83(1,1,1,3) | Details |
| 9326454 | Alston WK, Elliott DA, Epstein ME, Hatcher VB, Tang M, Lowy FD: Extracellular matrix modulates endothelial cell susceptibility to Staphylococcus aureus. J Cell Physiol. 1997 Oct;173(1):102-9. Endothelial cells were more susceptible to S. aureus infection when 1) grown on heparitinase-treated extracellular matrix that removed chains, 2) grown on extracellular matrix produced by -treated endothelial cells that reduced sulfation in the matrix heparan sulfate proteoglycans, 3) grown on purified from extracellular matrix elaborated by infected endothelial cells, and 4) endothelial cells were -treated and therefore expressed desulfated cellular heparan sulfate proteoglycans. |
3(0,0,0,3) | Details |
| 8735591 | McFarlane JR, Laslett A, de Kretser DM, Risbridger GP: Evidence that binding autocrine factors modulate production by the adult rat Leydig cell. Mol Cell Endocrinol. 1996 Apr 19;118(1-2):57-63. Their actions are mediated through cell surface or extracellular matrix proteoglycans and the aim of this study was to determine the role of cell surface heparan sulfate proteoglycans in the regulation of secretion by adult rat Leydig cells. The presence of sodium chlorate (25 mM) and protamine (10 micrograms/ml) inhibited production by LH stimulated cells by over 50%, but had no effect on unstimulated cells. |
2(0,0,0,2) | Details |
| 8986623 | Delehedde M, Deudon E, Boilly B, Hondermarck H: Heparan sulfate proteoglycans play a dual role in regulating fibroblast growth factor-2 mitogenic activity in human breast cancer cells. Exp Cell Res. 1996 Dec 15;229(2):398-406. To investigate the potential regulation of FGF-2 mitogenic activity by heparan sulfate proteoglycans (HSPG), we have treated human breast cancer cells by glycosaminoglycan degrading enzymes or a metabolic inhibitor of proteoglycan sulfation: sodium chlorate. |
32(0,1,1,2) | Details |
| 1885587 | Hoogewerf AJ, Cisar LA, Evans DC, Bensadoun A: Effect of on the sulfation of lipoprotein lipase and heparan sulfate proteoglycans. J Biol Chem. 1991 Sep 5;266(25):16564-71. To test further this hypothesis, the binding capacity of the plasma membrane for the lipase was decreased by inhibiting the sulfation of glycosaminoglycans with sodium chlorate, an inhibitor of adenyltransferase. |
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| 18046710 | Schulze A, Gripon P, Urban S: Hepatitis B virus infection initiates with a large surface protein-dependent binding to heparan sulfate proteoglycans. Hepatology. 2007 Dec;46(6):1759-68. Enzymatic removal of defined acidic carbohydrate structures from the cell surface using heparinase I/III or the obstruction of GAG synthesis by sodium chlorate inhibited HBV infection of HepaRG cells and, moreover, led to a reduction of HBV cell surface binding sites. |
3(0,0,0,3) | Details |
| 16507142 | Santiago B, Baleux F, Palao G, Gutierrez-Canas I, Ramirez JC, Arenzana-Seisdedos F, Pablos JL: CXCL12 is displayed by rheumatoid endothelial cells through its basic amino-terminal motif on heparan sulfate proteoglycans. Arthritis Res Ther. 2006;8(2):R43. Epub 2006 Feb 3. Desulfation of RA EC HSPGs by pretreatment with sodium chlorate, or by replacing in a synthetic CXCL12alpha the residues Lys24 and Lys27 by Ser (CXCL12alpha-K2427S), decreased or abrogated the ability of the chemokine to bind to RA ECs. |
2(0,0,0,2) | Details |