| 3118948 |
Rogers JI, Mukherjee J, Khalifah RG: Interaction of amide inhibitors with the active site of carbonic anhydrase: metal-induced deprotonation of the bound amide group is indicated by slow binding kinetics, by visible spectra of complexes with cobalt enzyme, and by pH effects on binding affinity. Biochemistry. 1987 Sep 8;26(18):5672-9.
The complex pH profile for inhibition of CA I by the ambivalent oxamate is consistent with coordination through the carboxylate group at low pH and through the deprotonated amide group at high pH. |
165(2,2,2,5) |
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