| Name | HADH |
|---|---|
| Synonyms | 2 enoyl CoA hydratase; Hydroxyacyl CoA dehydrogenase; HADH; 2 enoyl Coenzyme A hydratase; HADHB; Hydroxyacyl Coenzyme A dehydrogenase; MSTP029; TP beta… |
| Name | oxamate |
|---|---|
| CAS | hexyl 2-(diethylamino)-2-oxoacetate |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 15761599 | Chena MA, Elizondo-Jimenez S, Rodriguez-Paez L, Nogueda-Torres B, Baeza-Ramirez I, Wong-Ramirez C: Trypanosoma cruzi: inhibition of alpha-hydroxyacid dehydrogenase isozyme II by N-allyl and N-propyl oxamates and their effects on intact epimastigotes. Mem Inst Oswaldo Cruz. 2004 Dec;99(8):831-7. Epub 2005 Mar 4. The attachment of the allylic and propylic chains to of the competitive inhibitor oxamate (Ki = 0.91 mM, IC50 = 4.25 mM), increased 12.6 and 13-folds respectively, the affinity for T. cruzi HADH-isozyme II. |
84(1,1,1,4) | Details |
| 14506918 | Elizondo S, Chena MA, Rodriguez-Paez L, Nogueda B, Baeza I, Wong C: Inhibition of Trypanosoma cruzi alpha-hydroxyacid dehydrogenase-isozyme II by N-isopropyl oxamate and its effect on intact epimastigotes. J Enzyme Inhib Med Chem. 2003 Jun;18(3):265-71. The attachment of the nonpolar isopropylic branched chain to the of oxamate increased 12-fold the affinity of N-isopropyl oxamate for the active site of T. cruzi HADH-isozyme II. |
38(0,1,2,3) | Details |