| Name | vascular endothelial growth factor |
|---|---|
| Synonyms | VEGF; VEGF A; VEGFA; VPF; Vascular endothelial growth factor A; Vascular endothelial growth factor A precursor; Vascular permeability factor; vascular endothelial growth factor… |
| Name | oxamate |
|---|---|
| CAS | hexyl 2-(diethylamino)-2-oxoacetate |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 17567242 | Hunt TK, Aslam RS, Beckert S, Wagner S, Ghani QP, Hussain MZ, Roy S, Sen CK: Aerobically derived lactate stimulates revascularization and tissue repair via redox mechanisms. Antioxid Redox Signal. 2007 Aug;9(8):1115-24. Furthermore, inhibition of lactate dehydrogenase by using oxamate also prevented the angiogenic effects of lactate. They induced little inflammation but considerable VEGF production and were highly angiogenic, as opposed to controls. |
2(0,0,0,2) | Details |
| 18710947 | Milovanova TN, Bhopale VM, Sorokina EM, Moore JS, Hunt TK, Hauer-Jensen M, Velazquez OC, Thom SR: Lactate stimulates vasculogenic stem cells via the thioredoxin system and engages an autocrine activation loop involving hypoxia-inducible factor 1. Mol Cell Biol. 2008 Oct;28(20):6248-61. Epub 2008 Aug 18. SPC recruitment and protein changes were inhibited by siRNA specific to lactate dehydrogenase, TrxR, or HIF-1 and by oxamate, apocynin, U0126, dithioerythritol, and antibodies to VEGF or SDF-1. |
32(0,1,1,2) | Details |
| 19023021 | Milovanova TN, Bhopale VM, Sorokina EM, Moore JS, Hunt TK, Hauer-Jensen M, Velazquez OC, Thom SR: Hyperbaric stimulates vasculogenic stem cell growth and differentiation in vivo. J Appl Physiol. 2009 Feb;106(2):711-28. Epub 2008 Nov 20. Cell recruitment to Matrigel and protein synthesis responses were abrogated by N-acetyl dithioerythritol, oxamate, apocynin, U-0126, neutralizing anti-vascular endothelial growth factor, or anti-stromal cell-derived factor-1 antibodies, and small inhibitory RNA to Trx reductase, lactate dehydrogenase, gp91 (phox), HIF-1 or -2, and in mice conditionally null for HIF-1 in myeloid cells. |
32(0,1,1,2) | Details |