Protein Information

Name cyclooxygenase 1
Synonyms COX 1; COX1; COX 3; COX3; Cyclooxygenase 1; Cyclooxygenase 3; Cycloxygenase 1; Cycloxygenase 3…

Compound Information

Name eugenol
CAS 2-methoxy-4-(2-propen-1-yl)phenol

Reference List

PubMed Abstract RScore(About this table)
19501497 Raghavendra RH, Naidu KA: Spice active principles as the inhibitors of human platelet aggregation and thromboxane biosynthesis. Prostaglandins Leukot Essent Fatty Acids. 2009 Jul;81(1):73-8. Epub 2009 Jun 6.

Eugenol and capsaicin inhibited thromboxane B2 (TXB2) formation in platelets in a dose-dependent manner challenged with AA apparently by the inhibition of the cyclooxygenase (COX-1).
81(1,1,1,1) Details
10782484 Kelm MA, Nair MG, Strasburg GM, DeWitt DL: Antioxidant and cyclooxygenase inhibitory phenolic compounds from Ocimum sanctum Linn. Phytomedicine. 2000 Mar;7(1):7-13.

Eugenol demonstrated 97% cyclooxygenase-1 inhibitory activity when assayed at 1000-microM concentrations.
32(0,1,1,2) Details