| Name | mitogen activated protein kinases (protein family or complex) |
|---|---|
| Synonyms | MAPK; mitogen activated protein kinase; mitogen activated protein kinases |
| Name | eugenol |
|---|---|
| CAS | 2-methoxy-4-(2-propen-1-yl)phenol |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 16041649 | Chan AS, Pang H, Yip EC, Tam YK, Wong YH: Carvacrol and eugenol differentially stimulate intracellular Ca2+ mobilization and mitogen-activated protein kinases in Jurkat T-cells and monocytic THP-1 cells. Planta Med. 2005 Jul;71(7):634-9. Both carvacrol and eugenol are also capable of stimulating the active phosphorylation of the p38 subgroup of mitogen-activated protein kinases (MAPKs) in both cell types. |
168(2,2,3,3) | Details |
| 17698059 | Choi CY, Park KR, Lee JH, Jeon YJ, Liu KH, Oh S, Kim DE, Yea SS: suppression of inducible synthase expression is mediated by down-regulation of NF-kappaB, ERK1/2, and p38 kinase. Eur J Pharmacol. 2007 Dec 8;576(1-3):151-9. Epub 2007 Jul 26. In addition, blocked signaling upstream of NF-kappaB activation, such as degradation of I-kappaBalpha and the phosphorylation of extracellular signal-regulated kinases 1 and 2 (ERK1/2) and p38 mitogen-activated protein kinase (MAPK), in LPS-stimulated RAW 264.7 cells. The analogues eugenol and allylbenzene also inhibited LPS-induced NF-kappaB signaling and iNOS expression, albeit with less potency than |
1(0,0,0,1) | Details |
| 10871845 | Chainy GB, Manna SK, Chaturvedi MM, Aggarwal BB: Anethole blocks both early and late cellular responses transduced by tumor necrosis factor: effect on NF-kappaB, AP-1, JNK, MAPKK and apoptosis. Oncogene. 2000 Jun 8;19(25):2943-50. Besides NF-kappaB, anethole also suppressed TNF-induced activation of the transcription factor AP-1, c-jun N-terminal kinase and MAPK-kinase. The anethole analogues eugenol and also blocked TNF signaling. |
1(0,0,0,1) | Details |