| Name | microsomal epoxide hydrolases |
|---|---|
| Synonyms | EPHX; EPHX 1; EPHX1; EPHX1 protein; EPOX; Epoxide hydratase; Epoxide hydrolase; Epoxide hydrolase 1… |
| Name | eugenol |
|---|---|
| CAS | 2-methoxy-4-(2-propen-1-yl)phenol |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 1521503 | Luo G, Qato MK, Guenthner TM: Hydrolysis of the 2',3'-allylic epoxides of allylbenzene, estragole, eugenol, and by both microsomal and cytosolic epoxide hydrolases. Drug Metab Dispos. 1992 May-Jun;20(3):440-5. 2',3'-Allylic epoxide derivatives of allylbenzene and its analogs estragole, eugenol, and were synthesized, and their enzymatic conversion to dihydrodiols by cytosolic and microsomal epoxide hydrolases was examined. |
84(1,1,1,4) | Details |
| 8886614 | Luo G, Guenthner TM: Covalent binding to DNA in vitro of 2',3'-oxides derived from allylbenzene analogs. Drug Metab Dispos. 1996 Sep;24(9):1020-7. Epoxidation at the allylic side chain is a major metabolic pathway for allylbenzene and its naturally occurring analogs estragole, and eugenol. Epoxide hydrolases can prevent the binding of allylbenzene 2',3'-oxide to DNA in vitro. |
1(0,0,0,1) | Details |
| 11006409 | Burkey JL, Sauer JM, McQueen CA, Sipes IG: Cytotoxicity and genotoxicity of methyleugenol and related congeners-- a mechanism of activation for methyleugenol. Mutat Res. 2000 Sep 20;453(1):25-33. We were interested in the cytotoxicity and genotoxicity caused by methyleugenol and other alkenylbenzene compounds: (a known hepatocarcinogen), eugenol, and |
0(0,0,0,0) | Details |