| Name | Acetylcholinesterase |
|---|---|
| Synonyms | ACHE; ACHE protein; AChE; ARACHE; AcChoEase; Acetylcholine acetylhydrolase; Acetylcholinesterase; Acetylcholinesterase isoform E4 E6 variant… |
| Name | eugenol |
|---|---|
| CAS | 2-methoxy-4-(2-propen-1-yl)phenol |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 18810999 | Orhan I, Kartal M, Kan Y, Sener B: Activity of essential oils and individual components against acetyl- and butyrylcholinesterase. Z Naturforsch C. 2008 Jul-Aug;63(7-8):547-53. We have tested acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities of nineteen essential oils obtained from cultivated plants, namely one from Anethum graveolens L. (organic fertilizer), two from Foeniculum vulgare Mill. collected at fully-mature and flowering stages (organic fertilizer), two from Melissa officinalis L. (cultivated using organic and chemical fertilizers), two from Mentha piperita L. and M. spicata L. (organic fertilizer), two from Lavandula officinalis Chaix ex Villars (cultivated using organic and chemical fertilizers), two from Ocimum basilicum L. (green and purple-leaf varieties cultivated using only organic fertilizer), four from Origanum onites L., O. vulgare L., O. munitiflorum Hausskn., and O. majorana L. (cultivated using organic fertilizer), two from Salvia sclarea L. (organic and chemical fertilizers), one from S. officinalis L. (organic fertilizer), and one from Satureja cuneifolia Ten. (organic fertilizer) by a spectrophotometric method of Ellman using ELISA microplate-reader at 1 mg/ml concentration. In addition, a number of single components widely encountered in most of the essential oils 4-allyl anisole, (-)-carvone, dihydrocarvone, (-)-phencone, cuminyl cumol, 4-isopropyl benzaldehyde, trans-anethole, camphene, iso-borneol, (-)-borneol, L-bornyl 2-decanol, 2-heptanol, methyl-heptanol, nerol, iso-pulegol, citral, citronellal, citronellol, linalool, alpha-pinene, beta-pinene, piperitone, iso-menthone, menthofurane, linalyl oxide, linalyl ester, geranyl ester, carvacrol, vanilline, and eugenol] was also screened for the same activity in the same manner. |
1(0,0,0,1) | Details |
| 18814203 | Kumar P, Singh VK, Singh DK: Kinetics of enzyme inhibition by active molluscicidal agents umbelliferone, eugenol and in the nervous tissue of snail Lymnaea acuminata. Phytother Res. 2009 Feb;23(2):172-7. and umbelliferone are competitive, whereas eugenol and are competitive-non-competitive and uncompetitive inhibitors of acetylcholinesterase, respectively. |
112(1,2,2,2) | Details |
| 19358605 | Dohi S, Terasaki M, Makino M: Acetylcholinesterase Inhibitory Activity and Chemical Composition of Commercial Essential Oils. J Agric Food Chem. 2009 Apr 9. Among the essential oil components, five components, namely, alpha-pinene, eugenol, alpha-terpineol, and terpinen-4-ol, showed AChE inhibitory activity, with IC (50) values of 0.015, 0.022, 0.48, 1.3, and 3.2 mg/mL, respectively. |
67(0,2,2,7) | Details |
| 12828253 | Ingvast-Larsson JC, Axen VC, Kiessling AK: Effects of on in vitro neuromuscular blockade of rat phrenic nerve-diaphragm preparations. Am J Vet Res. 2003 Jun;64(6):690-3. Neostigmine restored this transmission by inhibiting acetylcholinesterase, which led to increased concentrations of |
1(0,0,0,1) | Details |