| Name | UGT2B15 |
|---|---|
| Synonyms | HLUG 4; UDPGT; HLUG4; UDP glucuronosyltransferase 2 family polypeptide B15; UDP glucuronyltransferase family 2 beta 15; UDP glycosyltransferase 2 family polypeptide B15; UDP glucuronosyltransferase 2B15 precursor; UDP glucuronosyltransferase UGT2B15… |
| Name | eugenol |
|---|---|
| CAS | 2-methoxy-4-(2-propen-1-yl)phenol |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 7835232 | Green MD, Oturu EM, Tephly TR: Stable expression of a human liver UDP-glucuronosyltransferase (UGT2B15) with activity toward steroid and xenobiotic substrates. Drug Metab Dispos. 1994 Sep-Oct;22(5):799-805. Apparent KM and enzyme efficiency values for certain food-derived substrates (e.g., and eugenol) for expressed UGT2B15 were similar to those determined for endobiotic substrates, suggesting that some naturally occurring substances are good substrates for this enzyme and that glucuronidation of endogenous compounds could be affected by xenobiotics derived from dietary sources. |
85(1,1,1,5) | Details |
| 12386133 | Court MH, Duan SX, Guillemette C, Journault K, Krishnaswamy S, Von Moltke LL, Greenblatt DJ: Stereoselective conjugation of oxazepam by human UDP-glucuronosyltransferases (UGTs): S-oxazepam is glucuronidated by UGT2B15, while R-oxazepam is glucuronidated by UGT2B7 and UGT1A9. Drug Metab Dispos. 2002 Nov;30(11):1257-65. Similar results were obtained for other substrates, including eugenol, 4-methylumbelliferone, and androstane-3alpha-diol. |
6(0,0,0,6) | Details |
| 12695357 | Turgeon D, Carrier JS, Chouinard S, Belanger A: Glucuronidation activity of the UGT2B17 enzyme toward xenobiotics. Drug Metab Dispos. 2003 May;31(5):670-6. UDP-glucuronosyltransferase (UGT) 2B17 is one of the most important conjugating enzymes in androgen metabolism and shares more than 95% homology with UGT2B15. The higher glucuronidation activity was measured with alizarin (125 pmol x min (-1) x mg protein (-1)), whereas UGT2B17 conjugated eugenol, scopoletin, and galangin with glucuronidation rates of 102.5, 102, and 58 pmol x min (-1) x mg protein (-1), respectively. |
2(0,0,0,2) | Details |
| 8798464 | Beaulieu M, Levesque E, Hum DW, Belanger A: Isolation and characterization of a novel cDNA encoding a human UDP-glucuronosyltransferase active on C19 steroids. J Biol Chem. 1996 Sep 13;271(37):22855-62. UGT2B17 is 95% identical with UGT2B15 and 91% identical with UGT2B8. The major substrates are eugenol > 4-methylumbelliferone > dihydrotestosterone > androstane-3alpha, 17beta-diol (3alpha-diol) > testosterone > androsterone (ADT). |
1(0,0,0,1) | Details |